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Category: Volume 06 Issue 03 March 2018
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Title: Assessing the correlation of placental thickness with fetal weight in second and third trimester

Authors: Karami Rasoul, Borji Soheila, Soltani Mohammad, Memari Behzad, Faghihzadeh Soghrat, Masoumkhani Fatemeh

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i3.120

Abstract

Background: Many of the problems with childhood and adolescence are related to birth weight, which varies depending on the birth weight of the newborn. One of the most important factors affecting birth weight can be attributed to the adequacy of the placenta and the environment in the uterus. The placental thickness is one of the characteristics of the placenta, which indicates the adequacy of the villous tree arrangement in placenta and the available blood volume of the fetus; therefore, we decided to study the correlation between the placental thickness and the fetal weight in the second and third trimester of pregnancy to introduce an auxiliary, simple, inexpensive, and available method for assessing the weight of the fetus.

Method: Cross-sectional study was randomly selected on 214 pregnant women aged 15-45 years who were referred to the Zanjan University of Medical Sciences clinic in Zanjan during the second and third trimester of pregnancy from April 2017 to September 2017, performed. All pregnant women received written consent for participation in the program. Exclusion criteria included any systemic diseases or genetic disorders such as diabetes, hypertension, etc. Using Philips affinity 50G ultrasound device, the mean age of fetus and fetal weight was measured by measuring the biparietal diameter (BPD), head circumference (HC), femoral length (FL) and abdominal circumference (AC), and placental thickness was measured in attachment point the umbilical cord; then, the data were analyzed by multiple regression analysis.

Results: According to the analysis of statistical data, a significant correlation was found between the placental thickness in the second and third trimester of pregnancy with fetal weight at these times (r=0.539,p=0.005  ;r=0.541,p=0.005), per 100 g of fetus  gain in the second and 250 g in third trimester of pregnancy, the placental thickness increased of 1 millimeter in the second and 0.4 mm in the third trimester of pregnancy; Also, there was a significant correlation between the placental thickness in the second and third trimester of pregnancy with the fetal age at these times (r=0.602,p=0.005 ;r=0.536,p=0.005), for each 1 week increase in the age of the fetus in the second and third trimester of pregnancy, the thickness of placenta increase 0.89 mm in the second trimester and 0.81 mm in the third trimester of pregnancy; however, no significant correlation was found between the placental thickness and the fetal gender.

Conclusion: According to the results of the study, a higher sample size study is recommended to determine a nomogram to use the placental thickness as an auxiliary tool along with other methods to determine the gestational age and fetal weight in ultrasonography and the related software is designed and use in ultrasound devices.

References

  1. Salafia CM, Zhang J, Charles AK, Bresnahan M, Shrout P, Sun W, Maas EM. Placental characteristics and birthweight. Paediatric and perinatal epidemiology. 2008;22(3):229-39.
  2. Voskamp BJ. Prenatal detection of small for gestational age pregnancies2014.
  3. Faienza MF, Brunetti G, Delvecchio M, Zito A, De Palma F, Cortese F, et al. Vascular function and myocardial performance indices in children born small for gestational age. Circulation Journal. 2016(0).
  4. Herman T, Sonnenschein-van der Voort AM, de Jongste JC, Anessi-Maesano I, Arshad SH, Barros H, et al. Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children. Journal of Allergy and Clinical Immunology. 2016;137(4):1026-35.
  5. Katz J, Lee ACC, Kozuki N, Lawn JE, Cousens S, Blencowe H, et al. Mortality risk in preterm and small-for-gestational-age infants in low-income and middle-income countries: a pooled country analysis. The Lancet.382(9890):417-25.
  6. Christian P, Lee SE, Donahue Angel M, Adair LS, Arifeen SE, Ashorn P, et al. Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries. International Journal of Epidemiology. 2013;42(5):1340-55.
  7. Lindner U, Tutdibi E, Binot S, Monz D, Hilgendorff A, Gortner L. Levels of cytokines in umbilical cord blood in small for gestational age preterm infants. Klinische Padiatrie. 2013;225(2):70-4.
  8. Baer RJ, Lyell DJ, Norton ME, Currier RJ, Jelliffe-Pawlowski LL. First trimester pregnancy-associated plasma protein-A and birth weight. European journal of obstetrics, gynecology, and reproductive biology. 2016; 198:1-6.
  9. Sanchez-Pintos P, Perez-Munuzuri A, Cocho JA, Fernandez-Lorenzo JR, Fraga JM, Couce ML. Evaluation of carnitine deficit in very low birth weight preterm newborns small for their gestational age. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2016;29(6):933-7.
  10. Tzschoppe A, Riedel C, von Kries R, Struwe E, Rascher W, Dorr HG, et al. Differential effects of low birthweight and intrauterine growth restriction on umbilical cord blood insulin-like growth factor concentrations. Clinical endocrinology. 2015;83(5):739-45.
  11. Zhong Y, Zhu F, Ding Y. Serum screening in first trimester to predict pre-eclampsia, small for gestational age and preterm delivery: systematic review and meta-analysis. BMC pregnancy and childbirth. 2015;15:191.
  12. Chisholm KM, Folkins AK. Placental and Clinical Characteristics of Term Small-for-Gestational-Age Neonates: A Case-Control Study. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2016;19(1):37-46.
  13. Yeung EH, McLain AC, Anderson N, Lawrence D, Boghossian NS, Druschel C, et al. Newborn Adipokines and Birth Outcomes. Paediatr Perinat Epidemiol. 2015;29(4):317-25.
  14. Noor N,Akanksha J,Shazia p,Syed Manazir A.Ultrasonographic measurement of placental thickness and its correlation with estimated fetal weight.Int J Reprod Contraseptive Obstet Gynecol.2018 Jan;7(1):287-290 .
  15. Ahn KH, Lee J, Cho GJ, Hong SC, Oh MJ, Kim HJ. P14. 19.Placental thickness to‐estimated foetal weight ratios and small‐for‐gestational age infants at delivery. Journal of Obstetrics & Gynecology. 2017;37(7):883-887.
  16. Jeelani H, Jabeen F, Qureshi A. GROSS MORPHOLOGICAL ALTERATIONS AND BIRTH WEIGHT IN GESTA-TIONAL DIABETES MELLITUS: A CASE-CONTROL STUDY. JK-Practitioner. 2015;20(1-2):17-20.
  17. Afrakhteh M,Moeini A,Sanei TM,Haghighatkhah H R.Correlation between placental thickness in the second and third trimester and fetal weight.Rev Bras Ginecol Obstet.2013;35(7):317-22.
  18. Ademola AA,Joyce EI.Relationship between two-dimensional ultrasound measurement of placental thickness and estimated fetal weight.Sahel Medical Journal.2015;18(1):4-8.
  19. Khairy SI,Mahgoub AA,Kunna A,Elkheir HA, Mohamed SE,Taha U. Estimation of placental thickness in third trimester to determine fetal weight in Sudanese women 2016.Res Rep Gynaecol Obstet. 2017;1(2):8-11.
  20. Preeti B, Vinita B, Rashmi P, Pomila S, Sonel O. Correlation of placental thickness estimated by-ultrasonography with gestational age and fetal outcome.IJNMR. 2015 Jul,3(3):19-24.
  21. Ali YAH, Ahmed Y. Association of Placental Thickness and Estimated Fetal Weight in pregnant Sudanese Women: Sudan University of Science and Technology; 2015.
  22. Pasty V, Lakshmi BS. Association between placental thickness and gestational age.JMSCR.2017 December;5 (12): 31788-31790.
  23. Arafa A , Alrashid R , Hamid O , Ala AE, Amin E .The correlation between placental thickness and fetal age among the pregnants in Sudan.SJAMS.2014; 2(1D):395-398.
  24. Sumit G, William M, Parul G . Correlation of ultrasonography estimate placental thickness age and fetal weight in late second and third trimester.AAI.2017 July-December; 3(2):49-51

Corresponding Author

Borji Soheila, MD

Assistant Professor of Radiology Department, Zanjan University of Medical Science ,

Zanjan, Iran, Mousavi Hospital, Gavazang road, Zanjan,

Tel:+982433130001, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.