Title: Autoimmune Hemolytic Anemia with Leukemoid Reaction as a Rare Extrahepatic Manifestation in Treatment Naïve Chronic Hepatitis C
Authors: Vikas Kumar Gupta, Pratibha Prasad, Shyam Sundar
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.72
Abstract
Primary autoimmune hemolytic anemia (AIHA) with leukemoid reaction is a rare extrahepatic manifestation of chronic hepatitis C virus (HCV) infection. However this can be successfully treated with prednisone therapy and does not form a contraindication to antiviral treatment. Hence, we report a case of direct Coombs’-positive AIHA with leukemoid reaction in treatment-naive 35-year-old Indian female with past medical history of chronic hepatitis C, genotype 1 who was successfully treated with prednisone therapy followed by pegylated interferon [PEG-IFN alfa-2a (180 μg/week)] plus ribavirin [RBV (1000 mg/day)] for 48 weeks. On follow up visit she had neither HCV infection nor AIHA.
Keywords: autoimmune hemolytic anemia (AIHA ), chronic hepatitis C.
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