Introduction: Bone lesions often pose diagnostic challenges to surgical pathologists. In the WHO classification, most bone neoplasms are classified as either benign or malignant. Therefore, an integrated approach involving radiographic, histologic, and clinical data are necessary to form an accurate diagnosis and to determine the degree of activity and malignancy of each lesion.

Materials and Methods: This is a retrospective study conducted in the Department of Pathology (histopathology section) at MGM medical college, Indore during a period of 2 years, All the histopathological reports and slides of patients who had bone tissue biopsies were reviewed to provide relevant information on age, sex, histopathological interpretation, and the anatomical site of occurrence. Data tabulation and analysis was done to deduce the relative frequency of all observed parameters

Results: A histopathological study of various bone lesions was carried out during 2 years, total 55 cases were studied. Bone lesions were more common in < 20 years age group (47.27%). Non-neoplastic lesions comprised 30 cases (54.5 %), 12 cases (21.8 %) had benign lesions and malignant lesions accounted for 13 cases (23.6%). Males (38 out of 55 cases, 69.1%) were affected more commonly. Amongst non-neoplastic lesions, chronic osteomyelitis (15 cases, 50.0 %) were commonest while giant cell tumour (07 cases, 58.33%) was more common in the category of benign neoplastic lesions. Among malignant tumours, sarcoma accounts for 06 cases (osteosarcoma 06, and Ewing’s sarcoma 05).

Conclusion: We conclude that the exact diagnosis of bone tumors is at times difficult. Therefore, an integrated use of clinical, radiological, and histopathological finding is recommended to increase accuracy of diagnosis and for better management of the patient.

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