Title: TBSRTC in LBC Preparation of Thyroid Lesions– Preferred over the Conventional Cytology
Authors: Dr Pranita Mohanty, Prof. (Dr) Debahuti Mohapatra
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.164
Abstract
Background: Fine Needle Aspiration (FNAC) is simple, easy & cost effective method adopted worldwide as a pre-/ post-operative diagnostic tool for any thyroid lesion. Yet it has it’s limitation. Hence in 2007 The Bethesda System of Reporting Thyroid Cytopathology(TBSRTC) was framed by National Cancer Institute (NCI) to improvise the conventional cytology (CP) into Liquid Base Cytology (LBC)
Material and Method: Present prospective study was conducted in our Cytopathology section over a period of three years (from January 2015 – December 2017). Total 315 patients with visible and palpable thyroid swelling were aspirated after taking consent, by 22-23 Gauge needle with the help of an aspirator under all aseptic measures. Then 2-3 dry smears were made and 2-3 smears were fixed in alcohol for conventional smear study (CP). Dry smears were stained with Diff Quik stain and alcohol fixed smears were stained with Hematoxylin & Eosin (H&E) and papanicolau (PAP) satin. Rest of the samples were put in the preservative solution and then processed for Liquid Based Cytology (LBC) preparation and stained with PAP stained.
Result: Total 315 thyroid cases were sampled for CP study & LBC could be done for 156 patients. Yet total 250 cases could be correlated for histopathology. Out of 156 patients of LBC, one patient did not turn up for surgery & 10 cases were in TBS grade I category.
In CP out of total 315 patients, only 250 cases were correlated and 15 cases were of grade I TBS category.
Then specificity, sensitivity, accuracy, FPR and FNR were calculated for both CP & LBC methods and was analysed with other studies.
Conclusion: LBC and TBS reporting system was found to be more comprehensive & communicative for Pathologist, Clinicians & patients with almost comparable sensitivity, specificity and accuracy.
Keywords: Thyroid, TBSRTC, LBC, CP.
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