Propofol, an intravenous anesthetic widely used for general anaesthesia cause severe pain in most of people. The aim of present study is to know the anti nociceptive effect of clonidine infusion with that of control (Normal saline) infusion immediately prior to propofol injection in alleviating Propofol injection pain (PIP). The present study was a randomized controlled study where in following the approval of the hospital's ethics Committee, 60 consenting adult patients were randomly divided into two groups A and B (n = 30) to receive 20 ml of normal saline as control and 0.5 μg/kg of clonidine diluted in 20 ml of normal saline respectively. The propofol injection pain was assessed according to the Mc Cririck and Hunter scale. The 27 patients in control group expressed pain compared to 18 patients in clonidine Group. In participants receiving clonidine  12(40%) were determined to be in Grade 0 according to Mc.Crick and Hunter Pain Scale,12(40%) patients were determined to be in Grade 1 and 5(16.67%) participants were in grade 2 followed by 1(3.33%) patients were detrmined to be in Grade 3according to Mc.Crick and Hunter Pain Scale. There is no significant difference between heart rate, Mean Arterial Pressures and haemodynamic side effects in both groups. Pre treatment with0.5 µg/kg of clonidine is effective in alleviating incidence and severity of propofol induced pain, did not cause significant hemodynamic adverse side effects.

Keywords: Propofol, Clonidine, Pain, Anaesthesia, Prevention, haemodynamic changes.

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Dr Somavarapu Sarwesh Kumar

Assistant Professor, Kamineni Institute of Medical Sciences and Research Center,

Hyderabad, Telangana State, India

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