Title: Etiological Factors Associated in Fever with Thrombocytopenia: A Clinical Study
Authors: Kamalasanan CG, Kaja Hussain S, Udayabhaskaran V
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.126
Abstract
Objective: This study was conducted to investigate factors associated in fever with thrombocytopenia
Patients and Methods: The present observational study was done on 200 patients attending Medicine department, Medical College, Kozhikode for a period of one year. A proforma was set for the conduction of study with special emphasis on clinical history, physical findings, haemogram, biochemical estimation and serological test.
Results: Fever with thrombocytopenia was most common in patients between 40 and 60 years of age. Leptospirosis was the most common cause of fever with thrombocytopenia followed by viral fever (excluding Dengue and viral hepatitis), scrub typhus and vivax malaria in that order. Bleeding manifestations were commonly seen in leptospirosis and to a lesser extent in scrub typhus. There was a decline in platelet count which was proportinate to the rise in total and neutrophil count, ESR and serum creatinine. Further, in this study, thrombocytopenia also have co-assocition with hypoalbuminemia in producing the complications observed such as bleeding manifestations, carditis, pancreatitis and ARDS.
Conclusion: Leptospirosis is most commonest cause of fever associated with thrombocytopenia along with the bleeding with the bleeding disorder and other serious complaications.
Keywords: Fever, thrombocytopenia, leptospirosis, bleeding disorder, hypoalbumenia.
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