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Category: Volume 06 Issue 02 February 2018
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Title: Role of Circulating C Reactive Protein in Thyroid Disorders

Authors: Naved Ahmad, Prof. Suryakant Nagtilak, Prof Anil Kumar Sharma M.D, Prof Pawan Parashar M.D, Assoc. Prof Amit Rastogi M.D, D.M (Endocrinology)

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.77

Abstract

Introduction: High sensitive C– reactive protein (hs-CRP) is an important sensitive inflammatory marker. Serum level of hs-CRP is not a routine investigation parameter to diagnose thyroid disorders, although many thyroid conditions involve inflammation. In the present study, the level of the hs-CRP and its association with thyroid disorders were assessed.

Material & Methods: A total of 91 males and 111 females, from the age group of 20 to 55 year were selected for the study. Estimation of hs-CRP was done on semi auto analyzer (Robonikread well touch ) by Enzyme immunoassay technique, the serum was also assayed for T3, T4 & TSH by enzyme linked florescent assay ( ELFA) technique using Vidas auto –analyzer.

Result: In our study we have found the Value of T3 in cases is 1.13± 0.88 nmol/L is high as compared to control group value 1.04± 0.28 nmol/L, Value of T4 in cases is 90.64 ±59.87 nmol/L as compared to control group value 92.47± 12.91 nmol/L, Values of TSH in cases is 7.15± 6.58 mIU/L is very high as compared to control group value 2.27 ±1.06 mIU/L. During our study we have also found values of hs CRP in cases 2.86± 0.97 mg/L as compared to control 1.89 ±0.62 mg/L

Conclusion: Our study findings suggest that abnormal thyroid hormones level interfere with the serum levels of hs–CRP which can have the implications related to Cardio vascular diseases.

Keywords: T3,T4,TSH, hsCRP & Thyroid Disorders.

References

  1. Tzoulaki I, Murray GD, Lee AJ, Rumley A, Lowe GD, Fowkes FG. C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study. Circulation. 2005; 112(7): 976-983.
  2. Fadel MB, Ellahham S, Ringel DM, Lindsay J, Wartofsky L, Burman DK. Hyperthyroid Heart Disease. Clinical Cardiology 2000; 23; 402-08.
  3. Polikar R, Burger GA, Scherrer U, Nicod P. The Thyroid and the Heart. Circulation 1993; 87; 1435-41
  4. Mushir Ahmad, Shahid Iqbal, Naved Ahmad, Iqbal Mohammad Khan. Thyroid dysfunction in the patients visiting Tertiary Health Care Hospital. Int J Med Sci Public Health 2016;5(10):2143-2145
  5. Unnikrishnan AG, Menon UV. Thyroid disorders in India: an epidemiological perspective. Indian J Endocrinology Metab 2011;15(6):78–81.
  6. Christ-Crain M, Meier C, Guglielmetti M, Huber PR, Riesen W, Staub JJ, et al. Elevated C-reactive protein and homocytsteine values: cardiovascular risk factors in hypothyroidism? A cross- sectional and double blind, placebo controlled trial. Atherosclerosis 2003;166(2):379–86.
  7. Jung CH, Sung KC, Shin HS, Rhee EJ, Lee WY, Kim BS, et al. Thyroid dysfunction to cardiovascular risk factors such as lipid profile, hs-CRP and waist hip ratio in Korea. Korean J Intern Med 2003;18(3):146–53.
  8. Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism may be associated with elevated high sensitive C-reactive protein (low grade inflam-mation) and fasting hyperinsulinemia. Endocrine J 2005;52(1):89–94
  9. Kochupillai N. Clinical Endocrinology in India. Current Science 2000; 1061-67.
  10. Uma Sudhan E, Rajagovindan D, Sumathi S. Thyroid hormones - its influence on the level and activity of nitric oxide and inflammatory marker among women with hypothyroidism. International Journal of Recent Trends in Science and Technology. 2014; 13(2): 363-367
  11. Ridker PM, Hennekens CH, Buring JE,  Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342(12):836-43.
  12. Christ-Crain M, Meier C, Guglielmetti M, Huber PR, Riesen W, Staub JJ, Müller B. Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial. Atherosclerosis. 2003; 166(2):379–86.
  13. Nagasaki T, Inaba M, Shirakawa K, Hiura Y, Tahara H, Kumeda Y,et al. Increased levels of C-reactive protein in hypothyroid patients and its correlation with arterial stiffness in the common carotid artery. Biomed Pharmacother. 2007; 61(2-3):167–72.
  14. Jublanc C, Bruckert E, Giral P, Chapman MJ, Leenhardt L, Carreau V, Turpin G. Relationship of circulating Creactive protein levels to thyroid status and cardiovascular risk in hyperlipidemic euthyroid subjects: low free thyroxine is associated with elevated hsCRP. Atherosclerosis. 2004; 172(1):7-11
  15. Esen Savas , Ahmet Ziya Sahin , Sefika Nur Aksoy , Ayse Tascan , Zeynel Abidin Sayıner , Mesut Ozkaya. Serum levels of inflammatory markers in patients with thyroid dysfunction and their association with autoimmunity status. Int J Clin Exp Med 2016; 9(2):4485-4490.
  16. Sharma R, Sharma TK, Kaushik GG, Sharma S, Vardey SK, Sinha M. Subclinical hypothyroidism and its association with cardiovascular risk factors.Clin Lab. 2011; 57(9-10):719-24.
  17. Agata Czarnywojtek, Maciej Owecki , Małgorzata Zgorzalewicz-Stachowiak , Kosma Wolin ´ski , Ewelina Szczepanek-Parulska , Bartłomiej Budny.  The Role of Serum C-Reactive Protein Measured by High-Sensitive Method in Thyroid Disease. Arch. Immunol. Ther. Exp. 2014; 62(6):501–509

Corresponding Author

Prof. Suryakant Nagtilak

Professor and Head Department of Biochemistry,

Shri Dev Suman Subharti Medical College, Dehradun, Uttarakhand, India

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