Most common histology of breast neoplasm is infiltrating ductal carcinoma. Primary osteosarcoma of breast is a rare histology. A 66-year-old postmenopausal female patient presented in outpatient department with a breast lump in right breast. Then core needle biopsy from right breast lump showed infiltrating ductal carcinoma. The disease became progressive even after multiple cycle chemotherapy. After toilet mastectomy, it showed osteosarcoma of breast. It is a rare case report which shows metaplastic change from an infiltrating duct carcinoma to osteosarcoma after chemotherapy.

Keywords: Infiltrating ductal carcinoma, osteosarcoma, mastectomy, metaplastic.

1. Bahrami A, Resetkova E, Ro JY, Ibañez JD, Ayala AG: Primary osteosarcoma of the breast: report of 2 cases.Arch Pathol Lab Med 2007, 131(5):792-5.
2. Remadi S, Doussis-Anagnostopoulu I, Mac GW:Primary osteosarcoma of the breast.Pathol Res Pract 1995, 191:471-474. 
3. Going JJ, Lumsden AB, Anderson TJ: A classical osteogenic sarcoma of the breast: histology, immunohistochemistry and ultr-astructure.Histopathology 1986, 10:631-641. 
4. Tavassoli F.A., Devilee P. — World Health Organization -pathology and genetics of tumors of the breast and female genital organs. Lyon: IARC, WHO classification of tumors. No. 4, 97-98, 2003.
5. Mertens HH, Langnickel D, Staedtler F: Primary osteogenic sarcoma of the breast. Acta Cytologica 1982, 26:512-516. 
6. Shimazu K, Funata N, Yamamoto Y, Mori T: Primary osteosarcoma arising in the colon: report of a case. Dis Colon Rectum 2001, 44:1367-1370. 
7. Minami H, Wakita N, Kawanishi Y, Kitano I, Sakata M, Shida T: Primary osteosarcoma of heart with severe congestive heart failure. Jpn J Thorac Cardiovasc Surg 2000, 48:607-609.  
8. Lee JS, Choi YD, Choi C: Primary testicular osteosarcoma with hydrocele. Virchow's Arch 2004, 445:210-213. 
9. Sacker AR, Oyama KK, Kessler S: Primary osteosarcoma of the penis. Am J Dermatopathol 1994, 16:285-287. 
10. Olgyai G, Horvath V, Kocsis J, Buza N, Olah A: Extraskeletal osteosarcoma in the gallbladder. Magy Seb 2003, 56:57-60. 
11. Cannon TC, Bane BL, Kistler D, Schoenhals GW, Hahn M, Leech RW, Brumback RA: Primary intracerebellar osteosarcoma arising within an epidermoid cyst. Arch Pathol Lab Med 1998, 122:737-739. 
12. Silver S.A., Tavassoli F.A. — Primary osteogenic sarcoma of the breast: a clinicopathologic analysis of 50 cases. Am J Surg Pathol. 22:925-933, 1998.
13. Suzuki T, Kikuchi K, Horiguchi Y, Nihei K, Asano S: Breast carcinoma with features of osteosarcoma-a light and electron microscopic and immunohisto-chemical study. Jap J Cancer Clin 1989, 35:1453-1460. 
14. Silver SA, Tavassoli FA:  Osteosarcom-atous differentiation in phyllodes tumors. Am J Surg Pathol 1999, 23:815-821. 
15. Sabaté JM, Gomez A, Torrubia S, Flotats A: Osteosarcoma of the Breast. Am J Roentgenol 2002, 179:277-278. 
16. Lumsden AB: Demonstration of a primary bone tumor of the breastby technetium-99m diphosphonate bone imaging. Clin Nucl Med 1986, 11:362. 
17. Lee JK, Sun SS: Primary osteogenic sarcoma of the breast demonstrated by Tc-99m MDP scintigraphy. Clin Nucl Med 1998, 23:619. 
18. O. Ogundiran, S. A. Ademola, O. M. Oluwatosin, E. E. Akang, and C. A. Adebamowo, “Primary osteogenic sarc-oma of the breast,” World Journal of Surgical Oncology, vol. 4, pp. 90–93, 2006. 
19. Khan S., Griffiths E.A., Shah N., et al. — Primary osteogenic sarcoma of the breast- A case report. Cases Journal. 1: 148, 2008.
20. Adem, C. Reynolds, J. N. Ingle, and A. G. Nascimento, “Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature,” British Journal of Cancer, vol. 91, no. 2, pp. 237–241, 2004. 
21. A. Silver and F. A. Tavassoli, “Osteosarcomatous differentiation in phyllodes tumors,” American Journal of Surgical Pathology, vol. 23, no. 7, pp. 815–821, 1999. 
22. J. Barrow, N. A. Janjan, H. Guzman et al., “Role of radiotherapy in sarcoma of the breast—a retrospective review of the M.D. Anderson experience,” Radiotherapy and Oncology, vol. 52, no. 2, pp. 173–178, 1999.
23. V. Singhal, Chintamani, and J. M. Cosgrove, “Osteogenic sarcoma of the breast arising in a cystosarcoma phyllodes: a case report and review of the literature,” Journal of Medical Case Reports, vol. 5, pp. 293–295, 2011.

Dr Minakshi Roy

2A2, Dreams Exotica, Bholanandapally, 79 Tilla Agartala Tripura India 799010

Ph: +91-9801276059, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.