Background: Diabetes is everywhere a most common growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. The study of plants that possess Antidiabetic activity may give a new idea in the treatment approaches of diabetes mellitus.

Objective:  The present study was aimed to evaluate the antihyperglycemic effect   of Aqueous extract of  Carica papaya linn. Leaves (AECPL) in alloxan‑ induced diabetic albino rats.

Methods: Albino rats weighing 150- 250 grams were grouped into 6 equal groups taking 6 rats in each. Group A served as control(normal), Group B as diabetic control, Group C, D & E was  receivedalloxan+ AECPL  suspension  at a doses  of  100,  200 & 400 mg/kg orally  respectively, Group F  was  givenalloxan + standard drug Glibenclamide (0.1mg/kg b.w.) suspension  for 21 days &  the AECPL  effect  on blood sugar  was measured at regular intervals. At the end of this research study blood samples were collected from all  rats for  biochemical estimation.

Results: The present study revealed that the AECPL has statistically significant (P < 0.05) and sustained Antihyperglycemic effect which is comparable with the hypoglycemic effect of standard drug Glibenclamide.

Conclusion: It is concluded  that  the  AECPL  has shown  significant  antihyperglycemic effect at  a  doses  of  100, 200 & 400 mg/kg. b.w. in  alloxan  induced  diabetic  albino  rats.

Keywords: AECPL, Glibenclamide, Antidiabetic, Aqueous extract, albino rats, blood sugar, glucometer, herbal remedy.

1. Tenpe C.R. and Yeole P.G. “Comparative evaluation of antidiabetic activity of some marketed polyherbal formulation in alloxan induced diabetic rats”. Journal of Pharma Tech Research, 2009; 1(1): 43-49.
2. Kurian JC. Plants that Heal. 2 ed. Oriental Watchman Publishing House Pune, India; 2001. 37: 55 p. 264-300.
3. Mohamed Isa SS, Riffi n S. The in-vitro antibacterial activity ofmethanol and ethanol extracts ofCarica papaya flowers and Mangiferaindica leaves. J Pharmacol Toxicol 2006;1:278-83.
4. Lohiya NK, Mishra PK, Pathak N, Munivannan B, Jain SC. Reversibleaz-ospermia by oral administration of the benzene chromatographic fraction of the chloroform extract of  the seeds of Carica papaya in rabbits. Adv Contracept 1999;15:141-61.
5. Satrija F, Nansen P, Murtini S, He S. Anthelmintic activity of papaya latex against patent Heligmosomoides polygyrus infections in mice. J Ethnopharm 1995;3:161-4.
6. Oladunmoye MK, Osho IB. Anti-inflammatory activity of ethanolic leaf extract from Carica papaya in rats, orogastricallydosed with Salmonella typhiand Staphylococcus aureus. JPlant Sci 2007;2:447-445.
7. The Wealth of India. Raw materials. Ca–Ci, Publication and Information Directorate, CSIR, New Delhi, India.1992. p. 287-93.
8. Tang CS, Syed MM, Hamilton RA. Benzyl isothiocyanatein the Caricaceae. Phytochemistry 1972;11:2531-3.
9. Emeruwa AC. Antibacterial substance from Carica papaya fruit extract. J Nat Prod.1982;45:123-7.
10. Asolkar LV, Kakkar KK, Chakre OJ. Glossary of Indian Medicinal Plants with active principles. Part 1 (A-K). Publications by Information Directorate, CSIR New Delhi. 1992.. 171-3.
11. Arvind G, Bhowmik D, Duraivel S, Harish G. Traditional and medicinal uses of Carica papaya, J Med Car Pap 2013; 1(1):2320-3862.
12. Dominguez de Maria P, Sinisterra JV, Tsai SW, Alcantara AR. Carica papaya lipase, an emerging and versatile biocatalyst, BiotechnolAdv 2006; 24(5):493-499.
13. Marotta F, Pavasuthipaisit K, Yoshida C, Albergati F, Marandolo P. Relationship between aging and susceptibility of erythrocytes to oxidative damage, in view of nutraceutical interventions, Rejuven Res 2006; 9(2):227-230.
14. SK Antidiabetic Agents. In : Drug Screening Methods. 2^nd Edition. New Delhi: Jaypee Brothers Medical Publishers; 2009. P 590-91.
15. Viana GS, Medeiros AC, Lacerda AM, Leal LK, Vale TG, Matos FJ. Hypoglycemic and anti-lipemic effects of the aqueous extract from Cissussicyoides.  BMC Pharmacol 2004;8:4-9.
16. Etuk Animals models for studying diabetes mellitus. AgricBiol J N Am 2010;1:130-4.
17. SK Gupta. Antidiabetic Agents-Drug Screening Methods. 2^nd New Delhi: Jaypee Brothers Medical Publishers; 2009, 590-91.
18. Etuk EU. Animals models for studying diabetes mellitus. AgricBiol J N Am2010;1:130-4.
19. Iranloye BO, Arikawe AP, Rotimi G, Sogbade AO. Anti-diabetic and antioxidant effects of ZingiberOfficinale on alloxan-induced and insulin-resistant diabetic male rats. Niger J PhysiolSci 2011;26:89-96.
20. Dunn JS, Sheehan HL, Mclethie NGB. Necrosis of islets of Langerhans produced experimentally. Lancet 1943;1;484-7.
21. Szkudelski T. The Mechanism of Alloxan and Streptozotocin Action in B Cells of the Rat Pancreas Physiol Res 2001;50:536-46.
22. Dhanesha N, Joharapurkar A, Shah G, Dhote V, Kshirsagar S, Bahekar R, Jain M. Exendin-4 activates glucokinase. J Diabetes 2012;inpress:doi: 10.1111/j.1753-0407.2012.00193.x

Dr Chakrapani Cheekavolu

Department of Pharmacology, Kerala Medical College and Hospital,

Mangode, Palakkad, Kerala, India,

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.