Title: Role of Saccharomyces Boulardii and Bacillus Clausii in Children with Acute Diarrhea – A Randomized Control Trial
Authors: Dr D.Vidjeadevan, Dr S. Ramesh, Dr Vinoth Selvaraj
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.186
Abstract
Background: Probiotics are live microorganisms which when administered confer benefits to host. They are recommended as add on therapy for acute diarrhea.
Objectives: To find out the effect of probiotics, Saccharomyces boulardii and Bacillus clausii on the duration of diarrhea in patients with acute diarrhea.
Material and Methods: This was a single blinded randomized controlled trial done with one group receiving ORS and zinc as per WHO recommendations and the other two groups along with ORS and zinc were receiving Saccharomyces boulardii and Bacillus Clausii respectively as probiotics.
Results: All the characteristics were equally distributed between the groups before intervention. There was significant reduction in the duration of diarrhea in the groups receiving probiotics as on add on therapy than the other group (p<0.05). No significant difference was found between the two groups receiving probiotic add on therapy.
Conclusion: Probiotics as an add on therapy would aid in decreasing the duration of diarrhea in acutepatients with acute diarrhea.
Keywords: Probiotics, Acute diarrhea, Saccharomyces boulardii, Bacillus clausii.
References
- Diarrhoeal disease [Internet]. WHO media centre. 2017. Available from: http://www.who.int/mediacentre/factsheets/fs330/en/
- Trivedi A, Ram R, Patel K. Epidemic investigation of an acute gastroenteritis outbreak in Daslana village of Ahmedabad, Gujarat. Natl J Med Res. 2013;3(3):267–9.
- Szajewska H, Guarino A, Hojsak I, Al E. European Society for Pediatric Gastroente-rology, Hepatology, and Nutrition. Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr. 2014;58:531–9.
- N J, Sudha M R. Bacillus clausii - The Probiotic of Choice in the Treatment of Diarrhoea. J Yoga Phys Ther [Internet]. 2015;5(4):1–4. Available from: http://www.omicsonline.org/open-access/bacillus-clausii--the-probiotic-of-choice-in-the-treatment-of-diarrhoea-2157-7595-1000211.php?aid=63792
- Canani RB, Cirillo P, Terrin G, Cesarano L, Spagnuolo MI, Vincenzo AD, et al. Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. Bmj [Internet]. 2007;335(7615):340–340. Available from: http://www.bmj.com/cgi/doi/10.1136/bmj.39272.581736.55
- Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and Safety of Saccharomyces boulardii for Acute Diarrhea. Pediatrics [Internet]. 2014;134(1):e176–91. Available from: http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2013-3950
- Das S, Gupta PK, Das RR. Efficacy and safety of saccharomyces boulardii in acute rotavirus diarrhea: Double blind randomized controlled trial from a developing country. J Trop Pediatr. 2016;62(6):464–70.
- Vandenplas Y, Brunser O, Szajewska H. Saccharomyces boulardii in childhood. Eur J Pediatr. 2009;168(3):253–65.
- Htwe K, Khin SY, Tin M, Vandenplas Y. Effect of Saccharomyces boulardii in the treatment of acute watery diarrhea in Myanmar children: A randomized controlled study. Am J Trop Med Hyg. 2008;78(2):214–6.
- Hospital MS, Saireddy S. Efficacy of Bacillus clausii Vs Saccharomyces boulardii in Treatment of Acute Rotaviral Diarrhea in Pediatric Patients. 2017;(June).