Title: KI 67 Expression in Pre-Malignant and Malignant Lesions of Oral Cavity
Author: Sachin Verma
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.161
Abstract
Introduction: Oral cancer is a major problem is India. In recent years more emphasis has been placed on cancer prevention programs and related studies. The most common maker used for detection of cell proliferation is Ki67 antigen. The aim of the study is to evaluate the diagnostic and prognostic significance of Ki67 expression in lesions of oral cavity.
Material and Methods: The study was carried out on 65 patients of pre-malignant and malignant lesions of oral cavity. Expression of Ki67 was studied on paraffin embedded section using immuno histo chemistry on all 65 cases using Ki67 diagnostic Kit.
Result: The mean ki67 labelling index for dysplasias is 25.45+3.31 and for carcinomas is 45.55+6.59. The difference is found to be statistically significant (p<0.05).
Conclusion: The expression of ki67 correlates well with the disease progression from dysplasias to carcinoma of oral cavity.
Keywords: ki67, oral cancer, premalignant, Dysplasia.
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