Objectives: To study the microbiological profile of neonatal septicemia and to determine the anti-microbial resistance pattern of isolated bacteria.

Study Design: retrospective analysis of blood culture reports of neonatal septicemia cases.

Setting:  tertiary level neonatal intensive care unit

Patients and Methods: case records of neonatal septicemia cases were retrieved and their culture results were analysed in terms of causative organisms and their antimicrobial sensitivity patterns. Extended spectrum beta lactamamse (ESBL) resistance and methicillin resistant Staphylococcus Aureus (MRSA) patterns were studied.

Results: out of 162 samples, bacterial growth was detected in 53 samples. Gram negative growth was around 66 percent and rest were gram positive. Gram negative organisms accounted for more than 75 percent in both early and late onset sepsis. Out of 12 blood cultures showing Staph Aureus, 7 (58%) were MRSA. Vancomycin was the drug to which all MRSA growths were sensitive. Out of 34 gram negative infections, 13 were ESBL in whom Klebsiella sp.  was the most common followed by  E. coli. All ESBL organisms were sensitive to Imipenem.

Conclusion: gram negative organisms predominated in the neonatal septicemia. MRSA and ESBL strains hold a large share of the bacterial growths.

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Dr Baljeet Maini

Professor, Department of Pediatrics, MMIMSR, Mullana

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