Lagenaria siceraria plant belongs to Cucurbitaceae family. It is common names as lauki (Hindi) and bottle gourd (English). It is used as medicine for its cardio tonic, general tonic and diuretic properties.

The present study evaluated the analgesic activity of Lagenaria siceraria in comparison to diclofenac. 5 groups of rats with 6 rats in each group were taken.1st group of 6 rats was kept as control. 2nd group of 6 rats were fed with standard diclofenac. The Third, fourth and fifth groups of 6 rats each were taken as test groups and administered with the crude extract of LAGENARIA SICERARIA in doses of 100, 200 and 400mg/kg body weight. The Analgesic Activity was evaluated by Tail flick analgesiometer and Hot plate method. The results of this study shows that the aqueous extract of Lagenaria siceraria fruit extract has potent analgesic activity which was evident in both-pain models used in this study.

Keywords: Lagenaria siceraria, analgesic activity, Swiss albino rats, aqueous extract of Lagenaria Siceraria (AELS) fruits, diclofenac (9 mg/kg)

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K. Harini

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