The research was conducted to study the various haemodynamic parameters (peak systolic velocity, end diastolic velocity, pulsatility index & resistivity index) using Colour Doppler Imaging in Ophthalmic artery in untreated patients of  primary open angle glaucoma and   the age matched healthy volunteers and the effect of anti-glaucoma treatment on these  parameters on subsequent follow-ups. Neither the patients nor the control subjects were using any systemic medication which can affect these parameters. Baseline differences between groups were assessed by Student’s t-test. Differences between groups (pre and post treatment) were determined using one-way ANOVA analysis. P ≤0.05 was considered the level of significance. All the glaucoma subjects showed some abnormalities of the ophthalmic artery blood flow parameters. Blood flow velocities were significantly (p<0.0001) decreased and resistivity index were significantly (p<0.0001) increased in glaucoma patients as compared to the control group. While the pulsatility index was significantly (p<0.0001) increased in the POAG group when compared to the normals. (p<0.003).

Anti glaucoma treatment caused normalization of hemodynamic parameters after treatment. Blood flow velocities (PSV, EDV) were increased from their baseline values and resistance to the blood flow in the ophthalmic artery was decreased after treatment as compared to the baseline. Pulsatility index was also normalized after the treatment in the POAG & and all the results were statistically significant. (p<0.0001).

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Atul Raut

Dr S.C.G.M.C.Nanded