Title: Homocysteine and Lipid Profile in Patients with Coronary Artery Disease
Authors: Jayarajan Karumarakkal, Mohan Raj Manjalavil
DOI: https://dx.doi.org/10.18535/jmscr/v5i9.122
Abstract
Aim of the study: To find out whether there is any significant correlation between concentrations of homocysteine level, hypercholesterolemia, diabetes mellitus, smoking and hypertension in coronary artery disease.
Background: Cardiovascular diseases are the major cause of morbidity and mortality worldwide. Diabetes mellitus, obesity, hypercholesterolemia, smoking and hypertension have been recognized as major risk factors for cardiovascular diseases. A new class of emerging risk factor is elevated plasma homocysteine level. This study aims to determine whether there is any significant association between homocysteine lipid profile and other parameters in acute coronary artery disease.
Objectives: 1. To determine the relation between homocysteine and coronary artery disease.
- To study the lipid profile and other parameters in patients with coronary artery disease in our population.
Settings and Design: Case control study in a tertiary care hospital, Kozhikode, Kerala.
Materials and Methods: Patients in the age group of 20 to 60 years with first attack of acute coronary artery disease of both sexes are included in this study. Sample size was 30 cases and 60 controls. Study period was one year. Levels of homocysteine, fasting lipid profile and other parameters are assessed.
Results: The levels of serum homocysteine, total cholesterol, LDL and fasting blood sugar showed significant increase in cases than in the controls. Triglycerides and HDL levels did not show any associated increase in patients with CAD.
Conclusion: The study reveals homocysteine, diabetes mellitus, hyperlipidemia, hypertension, obesity and smoking has definite role in the generation of coronary artery disease in the patients belonging to the District of Kozhikode.
Key Words: Homocysteine, fasting Lipid profile, coronary artery disease.
References
- Gilberto Garcia, Juanita Trejos, Beatriz Restrepo, et al : Homocysteine, Folate and Vitamin B12 in Colombian Patients with Coronary Disease, South America Colômbia Universidad Del Patricia Landázuri • Bolivar 12 N - Armenia (Quindio) Arq Bras Cardiol 2007; 89(2) : 71-76
- Nigel Unwin, Martin White, Raj Bhopal, Julie Yallop, Louise Walker et al : Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ 1999; July 24 319(7204):215-220.
- Gravina-Taddei CF, Batlouni M, Sarteschi C, Baltar VT, Salvarini NAC, Bertolami MC, et al: Hyperhomocysteinemia as a risk factor for coronary atherosclerotic diseases in the elderly. Arq Bras Cardiol. 2005; 85: 166-73.
- Kasper, Braunwald, Fauci, Hauser, Longo & Jameson : Harrison’s Principles of Internal Medicine, 17th edition page no 1427-28
- McCully KS: Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969; 56:111–128.
- Mudd SH, Skovby F, Levy HL, et al: The natural history of homocystinuria due to cystathionine b- synthase deficiency Am J Hum Genet 1985; 37:1–31
- Boushey CJ, Beresford SA, Ommenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995; 274 (13): 1049-57.
- Selhub J, Jaques PF, Wilson P, Rush D, Rosenberg IH: Vitamin status and intake as primary determinants of homocyst-einemia in and elderly population.JAMA. 1993; 270: 2693-
- Wald DS, Law M & Morris JK: Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002; 325: 1202.
- Schnyder G, Roffi M, Flammer Y: Effect of homocysteine – lowering therapy with folic - acid, vitamin B(12), and Vitamin B(6) on clinical outcome after percutan-eous coronary. Intervention: the Swiss Herat study a randomized controlled trial. JAMA. 2002; 288: 973-9.
- Dayton S, Chapman JM, Pearce ML, Popjak GJ: Cholesterol, atherosclerosis, ischemic heart disease, andstroke. Ann Intern Med. 1970; 72:97–109.
- Welin L, Svardsudd K, Wilhelmsen L, Larsson B & Tibblin G: Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med. 1987; 317:521–526.
- Kasper , Braunwald, Fauci , Hauser, Longo, Jameson Harrison’s Principles of Internal Medicine, 17th edition page no 1427-28.
- Deepa, K. Arvind and V. Mohan Diabetes and risk factors for coronary arterydisease Madras Diabetes Research Foundation, Gopalapuram, Chennai 600 086, India Current Science, Vol. 83, NO. 12, 25 December 2002 1497.