MI or AMI commonly referred as a heart attack occurs where flow of blood stops to part of the heart causing damage to the heart muscle. Increased Lipid profile levels are the major cause of Myocardial Infarction (MI). Myocardial infarction associated with Hyperthyroidism and patients with ischemic heart disease was a very high prevalence of hyperthyroidism. Patient having chest pain and increasing shortness of breath for many days are included in our study.

Purpose of the study: This study is designed to measure the level of thyroid hormone i.e. T3, T4, TSH and its correlation ship with lipid profile Ch, TG, LDL and VLDL in patients with acute myocardial infarction and control groups. The present showed that the level of total CH, TG, LDL-C and VLDL-C were significantly increased and significantly decreased in activity of HDL in AMI patients when compared to normal healthy control groups.

Similarly T3 and T4 levels were significantly increased in AMI patients when compared to control groups. Present study showed that the value of TSH decreased as compared to control groups. There was positive significant co-relation between T4 with CH and VLDL but there is no correlation found between T4 and HDL. The degree of T3 decrease is proportional to the severity of cardiac damage and may have a possible prognostic value.

Keywords: AMI, T3, T4, CH, TG, VLDL, HDL, CVD, CHD, Euthyroid sick syndrome, Coronary Artery Disease, CAD:  TSH: Thyroid Stimulating Hormone, ELISA, RIA, MIS.

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Dr Madhuri A. Agnihotri

Professor and HOD Dept. of Biochemistry,

CCM Medical College Kachandur, Durg Chhattisgarh 490024

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