Title: Diagnostic Yield of Various Procedures in Lung Cancer
Authors: Dr Sushant Muley, Dr Radha Munje, Dr Sanjay Gour, Dr Jitesh Atram
DOI: https://dx.doi.org/10.18535/jmscr/v5i9.49
Abstract
Background: Lung cancer is the most common cause of cancer related death worldwide. Early diagnosis is critical for initiation of specific therapy.
Aim and Objective: To study yield of various procedures in diagnosis of lung cancer.
Material and Methods: This prospective observational study was carried out at a tertiary care centre between December 2010 to august 2012. Total 60 patients presenting with clinical and radiological features suggestive of lung malignancy were studied. sputum cytology were done in all patients. Fibreoptic bronchoscopy, CT guided FNAC, pleural fluid cytology and biopsy were done in patients as per indication by the site of lesion.
Results: Sputum cytology was positive in 5 (8.33%) of patients. BAL cytology was positive in 31(58.49%) patients. Bronchial brush and punch biopsy were positive in 15(60%) and 7(63.63%) patients respectively. CT/ USG guided biopsy yielded diagnosis in 32 out of 35 (94.23%) patients. Pleural fluid aspiration and pleural biopsy yielded diagnosis in 46.66% and 73.33% patients respectively.
Conclusion: Bronchoscopy is useful tool for diagnosis of centrally located lung cancer while CT/USG guided lung biopsy is superior for peripherally located lung cancer. Pleural fluid biopsy is useful for diagnosis where pleural fluid cytology is negative for malignancy.
Key Words; Lung cancer, Fibreoptic bronchoscopy, pleural biopsy.
References
- Liesbet Schrevens, Natalie Lorent, et al. The Role of PET Scan in Diagnosis, Staging and Management of Non-Small Cell Lung Cancer.The Oncologist 2004;9:633- 643
- National Cancer Registry Programme. Three Year Report of Population Based Cancer Registries: 2009-2011. Indian Council of Medical Research; 2013. Available from: http:// ncrpindia.org
- Availablefrom:http://www.indiancancersociety.org/cancer‑registry/ cancer‑registry.aspx.
- Zavala DC. Diagnostic Fibreoptic Bronchoscopy: techniques and results in 600 patients. Chest 1975;68:12.
- Radke JR, Conway WA, Eyler WR, Kvale Diagnostic accuracy with peripheral lung lesion: factors producing success with fibreoptic bronchoscopy. Chest 1979;76:176-179.
- Pyrozynski M , Bronchoalveolar lavage in the diagnosis of peripheral primary lung cancer. Chest 1992;102: 372-374.
- Shiner RJ , Rosenman J , Katz L. Bronchoscopic evaluation of peripheral lung tumours. Thorax 1988;43:887-889.
- Baaklini WA, Reinoso MA, Gorin AB et al. Diagnostic yield of fiberoptic bronch-oscopy in evaluating solitary pulmonary nodules. Chest 2000;114(4):1049-1054
- Reicherberger F, Wever J, Tamm M. The value of transbronchial needle aspiration in the diagnosis of peripheral pulmonary lesions.Find all citations in this journal (default).Orfilter your current search Chest 1999;116(3):704-706.
- Somnath Bhattacharya, Tapan D Bairagya, Anirban Das, Abhijit Mandal, Sibes K Das. Closed pleural biopsy is still useful in the evaluation of malignant pleural effusion. Journal of laboratory physician 2012; 4 (1):35-38
- Jagdish Rawat, Girish Sindhwani, Dushyant Gaur, Ruchi Dua, Sunil Saini. Clinico-pathological profile of lung cancer in Uttarakhand Lung India 2009; 26(3):74-76.