Title: A Comparative Study of Small Dense low Density Lipoprotein levels in the Healthy and Diabetic Adult Individuals
Authors: Dr K. Harika Priyadarshini, Dr P.Nanda Kumar, B.Navya, Dr N.Vijaysam
DOI: https://dx.doi.org/10.18535/jmscr/v5i8.196
Abstract
The present study was carried out to identify the differences between small dense LDL levels in apparently healthy individuals and diabetic adults.
Materials and Methods: The study was conducted in male and female subjects (n =200) aged between 49-60 years who are not on any lipid lowering drugs. The estimation of small dense LDL levels was done by sd LDL methodology.
Results and Discussion: In this study we found that there is an increase in small dense LDL levels in diabetic cases than in normal healthy adult individuals.
Conclusion: Diabetes is closely associated with small dense LDL, an atherogenic particle. It should be considered as an independent, potential risk factor and as a diagnostic biomarker to be used in conjunction with other biochemical markers for early diagnosis, assessment and follow up of diabetic complications.
Keywords: Diabetes, small dense LDL, Biochemical marker, Atherosclerosis.
References
- Essam Abd-Allha, Basma Badr Hassan, Mohamad Abduo, Seham Ahmad Omar, Hamdy Sliem; Small dense low-density lipoprotein as a potential risk factor of nephropathy in type 2 diabetes mellitus; Indian Journal of Endocrinology and Metabolism / Jan-Feb 2014/Vol 18 |Issue 1
- Seema Abhijeet Kaveeshwar, Jon cornwall, the current state of diabetes mellitus in india, Australasian medical journal [AMJ 2014, 7, 1, 45-48]
- Gilson Soares Feitosa-Filho, Talita de Mattos Seydell, Alina Coutinho Rodrigues Feitosa, Raul Cavalcante Maranhão, José Antônio Franchini Ramires , Lipid Transfer to HDL in Type-2 Diabetic Patients: Associations with Microalbumi-nuria, Statin, and Insulin .Arq Bras Cardiol 2009;92(2):94-100
- Philipp A Gerber, Giatgen A Spinas & Kaspar Berneis. Small dense low-density lipoprotein particles: priority as a treat-ment target in Type 2 diabetes? Diabetes Manage. (2012) 2(1), 65–74 ISSN 1758-1907
- Ekaterina A. Ivanova, Veronika A. Myasoedova, Alexandra A. Melnichenko, Andrey V. Grechko, and Alexander N. Orekhov, Hindawi, Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases, Oxidative Medicine and Cellular Longevity, Volume 2017, Article ID 1273042, 10 pages
- Mutay Aslan, Filiz Ozcan, and Ertan Kucuksayan, Increased Small Dense LDL and Decreased Paraoxonase Enzyme Activity Reveals Formation of an Atherogenic Risk in Streptozotocin-Induced Diabetic Guinea Pigs, Journal of Diabetes Research Accepted 25 February 2013
- John J. Albers, April Slee, Jerome L.Fleg , Kevin D. O’Brien, Santica M. Marcovina, Relationship of baseline HDL subclasses, small dense Atherosclerosis 251 (2016) 454e459journal homepage: elsevier.com/locate/atherosclerosis
- Hao Shen, Yan Xu, Jingfen Lu Chunfang Ma, Yadong Zhou, Giong Li, Xu Chen, Ao Zhu and Guorong Shen, Shen et al; Small dense low density lipoprotein cholesterol was associated with future cardiovascular events in chronic kidney disease patients. BMC Nephrology (2016) 17:143.
- Ira J. Goldberg; Diabetic Dyslipidemia: Causes and Consequences, The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A
- Paul S. Jellinger, Chair; Yehuda Handelsman Paul D. RosenblitZachary T. Bloomgarden,; Vivian A. Fonseca, AlanJ.Garber ; American Association of Clinical Endocrinologists and American College of Endocrinology.Guidelines for management of dyslipidemia and prevention of cardiovascular disease endocrine practice, Vol 23 (suppl 2) April 2017
- Sheikh Ishaq, Iram Shabir, Arif A. Bhat, Imran Shafi, Saima Mushtaq, Parvaiz A. Shah1, Azra Baba2, Sabhiya Majid; Glycated Hemoglobin: A Marker of Circulating Lipids in Patients with Type 2 Diabetes from http://www.journalofdi-abetology.org on Friday, August 4, 2017, IP: 103.217.212.56]
- Toshiyuki Hayashia, Tsutomu Hiranoa, Takeshi Yamamotoa, Yasuki Itob, Mitsuru Adachia, . Intensive insulin therapy reduces small dense low-density lipoprotein particles in patients with type 2 diabetes mellitus: relationship to triglyceride-rich lipoprotein subspecies, JapanMetabolism Clinical and Experimental 55 (2006) 879– 884
- Jimimol Thomas, K. Krishnakumar, L. Panayappan, K. Jayapraksah, Atherogenic Dyslipidemia andits Management in Diabetes; (SAJP) ISSN 2320-4206 (Online), Sch. Acad. J. Pharm., 2015; 4(4): 245-248 ISSN 2347-9531 (Print).
- Sunghwan Suh, Hyung-Doo Park, Sang-Man Jin, Hye Jeong Kim, Ji Cheol Bae, So Young Park, Mi Kyoung Park, . Diabetes mellitus, but not small dense low-density lipoprotein, is predictive of cardiovascular disease: A Korean community-based prospective cohort study, Journal of Diabetes Investigation, Volume 4, Issue 6, and November 2013
- Nahla N Younis,Handrean Soran1, Reena Sharma, Valentine Charlton-Menys1, Adam Greenstein1, Mohamed M Elseweidyand Paul N Durrington1,Small-dense LDL and LDL glycation in metabolic syndrome and in statin-treated and non-statin-treated type 2 diabetes; Diabetes & Vascular Disease Research ,7(4) 289–295 .