Pemphigoid  gestationis or herpes gestationis is a subepidermal blistering disease that occurs in women in the second or third trimesters of pregnancy or even during puerperium. Its incidence has been estimated at around 1 case in every 40,000 to 60,000 pregnancies. Pruritus is an important symptom associated with the onset of disease. The lesions usually arise on the abdomen, often involving the umbilicus, and spread centrifugally .Women with a history of pemphigoid gestationis are at higher risk of developing Graves’ disease. Its clinical course is variable The gold standard to diagnose pemphigoid gestanosis is direct immunofluorescent  of perilesional skin , which shows bright linear deposition of C3 along the basement membrane in 100% cases. The main differential diagnosis is polymorphic eruption of pregnancy (PEP) which occurs later in the third trimester of pregnancy .Treatment of pemphigoid gestationis starts involves application of topical corticosteroids and/or lotions.

Keywords: pemphigoid , autoimmune, prurutis, pregnancy.

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Khushpreet Kaur

Professor, 19-Phulkian Enclave Patiala, Punjab 147001, (India)

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