Introduction: There have been many studies of association of Uveitis in cases of Ankylosing spondylitis but few of them only discussed the risk factors which could be associated with occurrence of Uveitis in AS .The study analyzed the risk factors of uveitis in patients with Ankylosing spondylitis.

Material and Methods: Total of 290 patients with AS were taken from September 2016 to June 2017. Retrospectively records were reviewed and information was collected accordingly, such as duration of disease, HLA-B27, and the number of patients with peripheral arthritis. Hip-joint lesion was seen by imaging. Biochemical examinations were performed to determine the patient’s physical function.

Result: Of 290 patients with AS (82.8% male, mean age 31.2 years), 28 (9.6%) had experienced 1 or more episodes of uveitis(Figure.1). Incidence rate for hip-joint lesion was obviously higher for patients with uveitis than the nonuveitis group (46.4% vs 21.3%; P<0.01). Number of patients with peripheral arthritis were more for the uveitis group than in non-uveitis group (2.23±0.26 vs 0.52±0.03; P<0.001). However, no significant differences in disease duration, HLA-B27, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP),was seen between these groups. Binary logistic regression results showed that the number of peripheral arthritis (OR=3.9, 95%CI:2.6–6.3, P<0.01) are significantly associated with uveitis in AS.

Conclusion: Therefore Hip joint lesion, peripheral arthritis could be associated with higher levels of Uveitis in cases of Ankylosing spondylitis and the possible occurrence of uveitis in AS should not be neglected in these patients who have such risk factors.

Keywords: Ankylosing Spondylitis, Hip joint lesion, peripheral arthritis, risk factors, uveitis

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Dr Akshat  Pandey

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