Title: Comparison of Gabapentin and Labetalol in Attenuating the Stress Response to Laryngoscopy and Intubation
Authors: Shahnawaz Khaliq, Tantry Tariq Gani, Sobia Manzoor, Khalid Sofi
DOI: https://dx.doi.org/10.18535/jmscr/v5i8.27
Abstract
Background: Laryngoscopy and tracheal intubation increase blood pressure (BP) and heart rate (HR). The aim of this study was to evaluate the effect of gabapentin and labetalol given before operation on the hemodynamic response to laryngoscopy and intubation.
Methodology: 90 ASA I and II patients undergoing elective surgery were randomly allocated to three groups of 30 each. Group A patients received 800mg of Gabapentine orally 60 minutes before induction of anaesthesia, Group B patients received 100 mg oral Labetalol 60 minutes prior to induction of anaesthesia and Group C patients were not given any treatment and served as the control group for the study. Anesthesia was induced with inj. propofol and inj. rocuronium. Heart rate, systolic BP, diastolic BP and mean arterial pressure were recorded as baseline, after induction, at tracheal intubation (0 min.); and then at 1, 3, 5, 10 min following tracheal intubation.
Results: mean heart rate, mean systolic blood pressure, mean diastolic blood pressure and mean arterial blood pressure remained significantly lower in group A as compared to group B and group C.
Conclusions: Gabapentin, under present study design, attenuates the pressor response associated with laryngoscopy and intubation.
Keywords: Intubation; Laryngoscopy; Gabapentin, Labetalol.
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