Aim: The objective of this study were to compare the reduction of cardiovascular response of ketamine between oral clonidine and intravenous lignocaine

Methods: In a randomized, prospective, parallel group, double blinded study, 150 patients were recruited and allocated into three groups. Group I( n=50) received ketamine 2mg/kg with normal saline 10 ml, Group II (n=50) received ketamine 2mg/kg with lignocaine 1.5mg/kg made upto 10ml and Group III (n=50) received ketamine 2mg/kg with oral clonidine 3mg/kg with normal saline 10ml. The patients were observed for pulse rate, systolic blood pressure, diastolic blood pressure, before induction and for 10 minutes after induction.

Results: The difference in pulse rate was much less in Group III 84.26 +/- 9.99) in comparision to Group I (99.14 +/- 15.11) bpm and Group II (93.48 +/- 14.86) bpm which is statistically significant (P= 0.0428). The mean arterial pressure of group III 100.2mm hg in comparision to group II 109.4 mm hg and group I :112.2 mm Hg was statistically significant ( P= 0.0006).

Conclusion: Oral clonidine attenuate the increase in heart rate and blood pressure of intravenous keatmine effectively than intravenous lignocaine in puerperal sterilization.

Keywords: pulse rate, mean arterial pressure, mean rate pressure product, ketamine, clonidine, lignocaine.

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Dr M.Lalitha MD.,DA

Professor & Head, Department of Anaesthesiology,

Government Theni Medical College, Theni, Tamilnadu