A total of 150 subjects were used for this study. Out of these numbers 50 were HIV-infected patients on Antiretroviral therapy (ART) and 50 were not on ART. The remaining 50 were screened HIV negative individuals drawn from the donation unit to serve as control. The subjects were made up of both sexes, ages ranging from 16 – 54 years. Blood samples were collected and analyzed for electrolytes such as Na⁺, K⁺, Cl, HCO₃^-, and serum urea and creatinine. Biochemical parameters were analyzed for mean±Standard Deviation, and student’s t-test for paired observation. All biochemical data were expressed as mean ± SD with the level of significance set at P < 0.05 confidence interval. There was a significant difference P < 0.05 in plasma creatinine and urea levels in patients with infected and treated (IAT) and infected and not treated (INT) when compared with controlled subjects. The  plasma creatinine level was also higher in INT than those of IAT with an insignificant difference. There was no significant difference in serum, Na⁺, K⁺_, Cl^-, HCO₃^- of IAT and INT when compared with control. Therefore this work recommends a periodic renal evaluation of HIV-infected patients to see the effect of the virus and probably drug on the serum electrolytes as this would help in the change of line of drug if effect or impairment is noticed early.

Keywords; HIV infected and treated, HIV infected untreated, serum electrolytes, Patients.

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Celestine.O.Ani

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