Title: Hepatic Transaminases Early Indicator of Dengue Fever Study Conducted In Rural Population of Northen India
Authors: Sushil Kumar, Ranjit Kumar Nim, Rajesh Kumar, Dheeraj Kela
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.224
Abstract
Aim of the study: Measurement of S.SGOT and SGPT and its use as a early indicator of Dengue Fever.
Material and Method: Study conducted in rural population of central India. 120 Positive cases of dengue fever was included in study out of which 72 male and 48 female patients.
The serum glutamic oxaloacetic transaminases (SGOT) and serum glutamic pyruvic transaminases (SGPT) were estimated by enzyme kinetic method by adding 100μl of patient’s serum with 1000μl of reagent and the concentration was read immediately in semi-automated analyser at340nm wavelength with 1cm optical path at 37oC temperature for 120 dengue positive cases.
Results: The serum glutamic pyruvic transaminases (SGPT) levels were found to be elevated more in females when compared with males. The serum glutamic oxaloacetic transaminases (SGOT) levels were also found to be higher in females. Overall, 70% of dengue fever cases of this study showed increased values of both SGOT and SGPT. SGOT was increased more compared to SGPT.
Conclusion: This study showed increased values of serum transaminases (SGOT&SGPT) reflects hepatic parenchymal demage and its rising level can be use as early indicator of Dengue Fever.
Keywords: Dengue fever, serum glutamic pyruvic transaminases, serum glutamic oxaloacetic transaminases, hepatic injury.
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