Liver disease is a general term for any damage that reduces the functioning of the liver. As a large organ, the liver shares with many other organs the ability to perform its functions with extensive reserve capacity.

Aim: aim of the study was study of serum markers in cirrhosis of liver and alcoholic liver disease.

Materials and Methods: The present study was done in the department of General Medicine at Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India. The present study was carried out on total 150 subjects aged between 35-60 years. Subjects were divided into three groups. 50 subjects were cirrhosis of liver and 50 were alcoholic liver disease. Control group which consist of 50 subjects who had no complain and history of liver disease.

Results and Discussion: The various enzymatic parameters included in LFT’S are Serum Bilirubin, SGOT, SGPT, GGT & ALP. These are useful to diagnose various liver diseases from the present study it is observed that in alcoholic Liver Disease shows a highest rise in Gama glutamyl transferase, high levels of GGT lives are the markers in the diagnosis of alcoholic liver disease. In cirrhosis of liver SGOT and SGPT levels are high these shows that these are the marker enzyme for cirrhosis of liver.

Conclusion: Further study is require for the diagnosis of markers in liver disease   

Keywords: Cirrhosis of liver, Alcoholic liver disease, SGOT,SGP,ALP.

1. "Alcoholic Liver Disease: Introduction". Johns Hopkins Medicine: Gastroentero-logy & Hepatology. Baltimore, MD: Johns Hopkins Hospital. 2010 
2. Stark J, et al. (1996). "Detection of the hepatitis G virus genome among injecting drug users, homosexual and bisexual men, and blood donors". Infect. Dis.174 (6): 1320–3.
3. "Alcoholic liver disease (per capita) (most recent) by country". NationMaster. _alc_liv_dis_percap-alcoholic-liver-disease-per-capita. Retrieved 29 July 2009.
4. Roguin A (2006). "Rene Theophile Hyacinthe Laënnec (1781-1826): the man behind the stethoscope". Clinical medicine & research4 (3): 230–5. H.U., Scheibe, P.and wanlefeld, a.w.,Clin, Chem.24:58,1978
5. Cirrhosis of the Liver at the National Digestive Diseases Information Clearinghouse (NDDIC). NIH Publication No. 04-1134, December 2003.
6. Chronic viral hepatitis British Medical Journal, Jan 27, 2001 by S D Ryder, I J Beckingham
7. International Medical Case Reports Journal,. Obstructive jaundice at the initial presentation in small-cell lung cancer Nobuaki Ochi, Nagio Takigawa, Masayuki Yasugi, et al Published Date February 2010 , Volume 2010:3 Pages 9 – 12.
8. Journal of Viral Hepatitis Volume 17 Issue 8, Pages 527 - 536Published Online: 8 Jun 2010 © 2010 Blackwell Publishing Ltd,. Control of hepatitis B virus at the level of transcription Quasdorff ¹ and U. Protzer
9. Rodriguez-Roisin R, Krowka Mj. Herve P, Fallon MB (2004). “ Pulmonary – Hepatic Vascular Disorders (PHD)” Eur. Respir. J.24 (5): 861 -80.
10. Journal of Antimicrobial Chemotherapy (2000) 45, 933 , 2000,. Therapies for Viral Hepatitis Robert S. Heyderman.
11. Li CP, Lee FY, Hwang SJ, et al.(1999). "Spider angiomas in patients with liver cirrhosis: role of alcoholism and impaired liver function". J. Gastroenterol.34 (5): 520–3.
12. Liver cirrhosis Dr Detlef Schuppan MD aNezam H Afdhal MD The Lancet, Volume 371, Issue 9615, Pages 838 - 851, 8 March 2008
13. Pessoa MG, Terrault NA, Detmer J, et al.(1998). "Quantitation of hepatitis G and C viruses in the liver: evidence that hepatitis G virus is not hepatotropic". Hepatology27 (3): 877–80
14. Pashankar, D; Schreiber, RA (July 2001). "Jaundice in older children and adolescents". Pediatrics in Review22 (7): 219–226.

Dr G.Anitha

Professor in Biochemistry, Fathima institute of Medical Sciences,

Kadapa, Andhra Pradesh India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.