Title: To Evaluate and Compare Therapeutic Effect of High Dose versus Low Dose Caffeine Citrate for Treatment of Apnea in Preterm Infants
Authors: Ashok Soni, B. S. Karnawat, Mukesh Sonkaria, Ishwar P Verma
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.94
Abstract
Background: The infant mortality rate (IMR) is one of the indicators used to monitor achievements towards the Millennium Development Goals.
Material and Methods: A total of 54 preterm infants <35 weeks gestation, presented with AOP within the first 14 days of life were enrolled and randomized into two groups 28 in high dose group (loading 40 mg/kg/day and maintenance of 20 mg/kg/day) and 26 in conventional dose group (loading 20 mg/kg/day and maintenance of 10 mg/kg/day).
Results: Total 57.14% infants required CPAP in high dose group, compared to 53.85% in conventional dose group. High dose caffeine was associated with a significant reduction in the need for indigenous bubble CPAP.
Conclusion: To conclude the use of high dose caffeine as compared to than conventional dose may decrease the recurrence of apnea, duration of oxygen therapy, NICU stay and requirement of mechanical ventilation in preterm infants without significant side effects.
Keywords: Apnea of prematurity (AOP). Caffeine. Preterm infants.
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