Title: Prevalence of Drug Utilization Patterns on Hypertensive Patients in Tertiary Care Hospital
Authors: Selvaraj Rajendran, Chakrapani Cheekavolu, N. Jagan
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.90
Abstract
Introduction: A Prospective Study on Prescribing Pattern and Utilization of Anti-Hypertensive Drugs in A Tertiary Care Teaching Hospital
Method: The Prospective observational study was conducted in Department of pharmacology, Kerala Medical College Hospital for a period of 6months. Total 500 prescriptions were analyzed in hypertensive patients of OPD medicine departments. Prescriptions were evaluated for prescribing pattern by using WHO drug use indicators.
Results: Out of 500 samples, 325 (65.00 %) were male and 175 (35.00 %) were female. The mean age of patients were 55.14 ±1.09, BMI was 27.21 ± 0.88kg/m2. The average no. of drugs/prescription was 3.44±1.41. A total of 1951 drugs were prescribed in overall study period. 520 (26.65%) were antihypertensives, 343 (17.58%) antidiabetic drugs, 374 (19.16%) NSAIDs, 114 (5.84%) Thyroid hormones, 54 (2.76%) Statins, 54 (2.76%) anti-anxiety/ antidepressants and 492 (21.44%) were miscellaneous. A total of 520 antihypertensive drugs were prescribed; Angiotensin Receptor blockers (ARBs) were 119 (22.88%), ACE inhibitors were 112 (21.53%). Beta blockers were 97 (18.65%), Ca+ channel blockers were 73 (14.03%) and other antihypertensive were 21(4.03%). Total 98 fixed dose combinations were used; Amlodipine and Atenolol 30 (30.61%) followed by Olmesartan and Hydrochlorthiazide 21 (21.42%), Losartan and Hydro-chlorthiazide 17 (17.34%), Ramipril+Hydrochlorthiazide 12 (12.24%), Telmisartan+ Hydrochlorthiazide 10 (10.20%) followed by Three drug combination of Olmesartan+Amlodipine +Hydrochlorthiazide 08 (8.1%).
Conclusion: Present study reveals that, male hypertensive patients are more than the female patients; most commonly prescribed drugs were antihypertensives, antidiabetic and NSAIDs. Antihypertensive drugs were ARBs, ACE inhibitors and combination therapy of Amlodipine with Atenolol.
Keywords: Hypertensive, Drug utilization, OPD, Tertiary care hospital.
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