Title: Study of KETODEX; Combination of Dexmedetomidine and Ketamine in Upper Gastrointestinal Scopy in Adults: Observational Study
Authors: Dr Bindya Kour Bali, Dr Alpa Patel
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.196
Abstract
Background: Aim of the study was to know clinical effects, safety and observe side effects of using the combination of dexmedetomidine and ketamine in upper gastrointestinal endoscopy in adults.
Material and Methods: A total of Sixty patients between the age group of (18 -60yrs) with American Society of Anesthesiologists class I, II or III undergoing UGIE were enrolled and an observational study was conducted over a period of 1 year. Dexmedetomidine (1.5 µg/kg) iv bolus was given slowly over 5min followed by ketamine (0.5 mg/kg) before starting the endoscopic procedure. Dexmedetomidine infusion was continued (0.5µgm/kg) and supplemental dose of ketamine was given if required .Heart rate, blood pressure and oxygen saturation, time to achieve Ramsay sedation score of 3-4 were recorded before induction, then every 5min untill recovery. The duration, ease of the procedure, time to recovery (Modified Aldrete Recovery Score) and complications if any were also recorded.
Results: UGIE could be performed with ease in 53 of the 60 cases (88.33%). No significant change in HR, Blood pressure, and Saturation (spo2) from the baseline values (p > 0.001). None of the cases experienced respiratory depression. No active airway intervention was required. Recovery profile was good.
Conclusion: Combination of dexmdetomidine and ketamine in UGIE procedure promises to be clinically effective and safe with good recovery profile .
Keywords: Dexmedetomidine, Ketamine ,Ketodex, Upper Gastrointestinal Endoscopy.
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