Title: Study of Peripheral Neuropathy in Chronic Kidney Disease Stage V Patients on Hemodialysis
Authors: Prof. Dr T.N. Dubey (DM), Prof. Dr K.K. Kawre (DM), Dr Rohan Gayakwad, Dr Nishant Shrivastava (MD)
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.171
Abstract
Introduction: End stage renal disease (ESRD) is commonly associated with peripheral neuropathy. This study was undertaken to observe prevalence, type and pattern of peripheral neuropathy in end stage renal disease patients being treated by haemodialysis
Material and Method: 50 patients of ESRD being treated by haemodialysis for duration more than 3 months were included in study. Diabetics were excluded. All patients were investigated with nerve conduction studies (NCV). Estimated glomerular filtration rate and modified total neuropathy score was calculated in each patient
Observations: 34 % patients had normal NCV report and 66% had abnormal report, out of which 26% patients had overt and 40% had subclinical neuropathy .maximum patients had axonal sensorimotor neuropathy involving all 4 limbs.
Conclusion: Present study finds out high prevalence of peripheral neuropathy in ESRD patients being treated haemodialysis. Majority of patients have overt or subclinical peripheral neuropathy which can be axonal demyelinating or both. Hence through this study we emphasis on calculation of modified total neuropathy score and nerve conduction study in every patient planned for maintaince haemodialysis.
References
1. Krishnan AV, Kiernan MC. Neurological complications of chronic kidney disease. Nature reviews Neurology. 2009;5 (10): 542–51. Peripheral neuropathy in patients in haemodialysis treatment 23
2. Nielsen VK. The peripheral nerve function in chronic renal failure. Acta Medica Scandinavica. 1971;190(1‐6):105–11 [Abstract].
3. Van den Neucker K, Vanderstraeten G, Vanholder AR. Peripheral motor and sensory nerve conduction studies in haemodialysis patients. A study of 54 patients. Electromyography and Clinical Neurophysiology. 1998;38(8):467–74. Peripheral neuropathy in patients in haemodialysis treatment 24
4. Bazzi C, Pagani C, Sorgato G, Albonico G, Fellin G, D’Amico G. Uremic polyne-uropathy: a clinical and electrophysi-ological study in 135 short- and long-term hemodialyzed patients. Clinical Nephr-ology. 1991;35(4):176–81 [Abstract].
5. Levey AS, Coresh J, Balk E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratific-ation. Ann Intern Med 2003; 139:137.