Title: To Study Clinical Profile and Complications of Plasmodium Vivax Malaria
Authors: Dr Chouhan A S, Dr Desai H, Dr. Kejriwal A, Dr Ghanekar J, Dr Pereira E
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.113
Abstract
Introduction
Malaria is caused by Plasmodium parasites. It is a protozoan disease transmitted by the bite of infected Anopheles mosquitoes called "malaria vectors.” Out of the five parasite species that cause malaria in humans, 2 of these species – P. falciparum and P. vivax– pose the greatest threat.1,2
Plasmodium vivax is geographically most widely distributed with upto 2.5 billion people at risk and an estimated 70-80 million cases every year (3).
Although Plasmodium vivax malaria has a huge burden on the health, longevity and general prosperity of the people, research on Vivax malaria and its complications are grossly overlooked and left in the shadow of the enormous problem caused by Plasmodium falciparum (3).
P. vivax can cause both sequestration related and non-sequestration related complications of severe malaria as defined by WHO, including cerebral malaria, renal failure, circulatory collapse, severe anemia, haemoglobinuria, abnormal bleeding, acute respiratory distress syndrome (ARDS), jaundice, and acidosis. (3)
References
WHO :Malaria. (2015). [online] Available at: http://www.who.int/mediacentre/factsheets/fs094/en/ [Accessed 3 Jan. 2016].
2. Longo D, Fauci A, Kasper D, Hauser S. Harrison's Principles of Internal Medicine 18th edition. McGraw-Hill Professional; 2011 Aug 11.
3. Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S, et al. Severe Plasm-odium vivax malaria: A report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg 2009;80:194-8
4. National Institute of Medical Research. Guidelines for diagnosis and treatment of malaria in India. 2009. New Delhi: NIMR/TRS – 06 April 2009. Available from www.mrcindia.org
5. Manning L, Laman M, Law I, Bona C, Aipit S, Teine D, et al. Features and prognosis of severe malaria caused by Plasmodium falciparum, Plasmodium vivax and mixed Plasmodium species in Papua New Guinean children. PLoS One. 2011;6(12):e29203. doi:10.1371/journal.pone.0029203.
6. Kochar DK, Tanwar GS, Khatri PC, Kochar SK, Sengar GS, Gupta A, et al. Clinical features of children hospitalized with malaria–A study from Bikaner, Northwest India. Am J Trop Med Hyg. 2010;83:981–9
7. Yadav D, Chandra J, Aneja S, Kumar V, Kumar P, Dutta AK. Changing profile of severe malaria in North Indian children. Indian J Pediatr. 2012;79:483–7.
8. Poespoprodjo JR, Fobia W, Kenangalem E, Lampah DA, Warikar N, Seal A, McGready R, Sugiarto P, Tjitra E, Anstey NM, Price RN. Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic. Clin Infect Dis. 2008;46:1374–1381. doi: 10.1086/586743.
9. McGready R, Lee SJ, Wiladphaingern J, Ashley EA, Rijken MJ, Boel M, Simpson JA, Paw MK, Pimanpanarak M, Mu O, Singhasivanon P, White NJ, Nosten FH. Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study. Lancet Infect Dis. 2012;12:388–396. doi: 10.1016/S1473-3099(11)70339-5.
10. Baird JK. Evidence and implications of mortality associated with acute Plasmodium vivax malaria. Clin Microbiol Rev. 2013;26:36–57.
11. Price RN, Douglas NM, Anstey NM. New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance. Curr Opin Infect Dis. 2009;22:430–435
12. Barcus MJ, Basri H, Picarima H, Manyakori C. Sekartuti, Elyazar I, Bangs MJ, Maguire JD, Baird JK: Demographic risk factors for severe and fatal vivax and falciparum malaria among hospital admissions in northeastern Indonesian Papua. Am J Trop Med Hyg. 2007;77:984–991.
13. Rodriguez-Morales AJ, Benitez JA, Arria M. Malaria mortality in Venezuela: focus on deaths due to plasmodium vivax in children. J Trop Pediatr. 2008;54:94–101
14. Patil DR, Nikumbh SD, Parulekar A, Roplekar K. Multiorgan Dysfunction in Plasmodium vivax Malaria: A Prospective Study. Int J Sci Stud 2015;3(5):155-162
15. Nadkar MY, Huchche AM, Singh R, Pazare AR. Clinical profile of severe Plasmodium vivax malaria in a tertiary care centre in Mumbai from June 2010 to January 2011.J Assoc Physicians Indi 2012;60:11-3.
16. O’Brien AT, Ramírez JF, Martínez SP A descriptive study of 16 severe Plasmodium vivax cases from three municipalities of Colombia between 2009 and 2013. Malar J 2014;13:404.
17. Bansal N, Uniyal N, Khrime D, Varma Status of severe Plasmodium Vivax Malaria in Uttarakhand (June 2010 –October 2013). Indian J Sci Res Technol 2014;2:30-4.
18. Apte S, Jain J, ParmarA, Apte A, Sinha U, Chanchlani R. A study of clinical profile in patients with P. Vivax malaria. J Evol Med Dent Sci2014;3:575-81.
19. Echeverri M, Echeverri M, Tobon A, Alvarez G, Carmona J, Blair S. Clinical and laboratory findings of Plasmodium vivax malaria in Colombia. Rev Inst Med Trop SaoPaulo 2003;45:29-34.
20. Jyoti Kharche, Vikramaditya Venkatesh Shinde, Bhushan Pagar, Pratik Patil, Nidhi Dahiya, To Study Clinicohe-matological Profile of Plasmodium Vivax Malaria Journal of Dental and Medical Sciences (IOSR-JDMS) 2016;Volume 15, Issue 3 Ver. I PP 22-27
21. Don Oh Myoung, Shin Hyungshik, Shin Donghyun, Kim Uiseok, Lee Sunhee, Kim Namjoong. Clinical features of vivax malaria. Am J. Trop. Med. Hyg.2001; 65(2): 143-6.
22. S. P. Singh, Ragini Singh, Niaz Ahmad, A comparative study of complications of vivax and falciparum malaria in Dehradun, India ,Int J Res Med Sci. 2014 Feb;2(1):117-121