Title: Association of Ischemia Modified Albumin with Pregnancy Induced Hypertension
Authors: Dr A.Mangala Geetha, MD DGO DNB, Viswanath Selvam, Vinodhini Shanmugam
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.109
Abstract
INTRODUCTION
Pre-eclampsia occurs in 5% to 8% of pregnancies worldwide and is the second leading cause of direct maternal and fetal deaths [1]. Its prevalence in India is 54% and 56.2% in urban and rural communities respectively. Its occurrence in Tamil Nadu is 47.4 % to 48.7%[2].
Pre-eclampsia affects both mother and fetus. It may lead to eclampsia, HELLP syndrome, ischemic stroke, liver dysfunction and acute respiratory distress syndrome (ARDS)[3].
Abnormal placental vascular development is the basis of common obstetric disorders such as preeclampsia and intrauterine growth restriction[4]. Preeclampsia associated with defective endovascular trophoblastic invasion and inadequate remodeling of uterine spiral arteries leads to hypoxic intrauterine environment and generation of reactive oxygen species (ROS) which is implicated in its pathogenesis[5].
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