Title: Salmonella Entericaserovars Showing Resistance to Azithromycin in A Tertiary Care Hospital From South India
Authors: Sumana M N, Satya Sai.B, Pooja P.B
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.97
Abstract
Introduction
Enteric fever is an important public health problem caused by salmonella species (typhoidal group) Salmonella enteric serovar typhi, Paratyphi A, Paratyphi B and Paratyphi C. WHO estimates 21.7 million cases every year with 217,000 deaths1. Without treatment enteric fever has a mortality rate of 30% if appropriately treated with the sensitive antibiotic, the mortality can be reduced to below 0.5%1. With the emergence of multi drug resistance Salmonella i.e Resistance to ampicillin, chloramphenicol and Co-trimoxazole, Fluroquinolones were being used (i.e Ciprofloxacin) or Ceftriaxone for the treatment of enteric fever1,2. With the extensive use of Fluroquinolones, Salmonella species are less susceptible to Ciprofloxacin (with the MIC of Nalidixic acid ≥32 µg/ml and that of ciprofloxacin ≤0.25µg/ml) emerged. Some strains of Salmonella especially Salmonella enteric serovar para typhi A shows resistance to Ciprofloxacin with MIC of ≥1 µg/ml also with the use of Ceftriaxone, it is found that slowly the time taken for fever defervesce is increasing.
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