Title: Hemodynamic Stress Response during Laparoscopic Cholecystectomy: Effect of Oral Administration of Moxonidine
Authors: Avijit Kumar Prusty, Jagannath Mishra
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.96
Abstract
Background: In the event of laparoscopic surgeries, pneumoperitoneum can prelude to wide array of pathophysiologic changes in the cardiovascular system which may overture to hypertension and tachycardia. Thus, search for an ideal pharmacological agent to prevent the hemodynamic response is vital.
Objective: Thus, the present study was undertaken to evaluate the effect of orally administered moxonidine in attenuating the hemodynamic responses that occur during the laparoscopic surgeries.
Patients and Methods: A total of 50 adult ASA I and II patients scheduled for elective laparoscopic surgeries were selected for the study. The patients were divided into two groups moxonidine group (M) and placebo group (P). M group received oral moxonidine 0.3 mg at 8 pm on the day before surgery and at 8 am on the day of surgery. P group received a placebo at the same timing as that of the M group.
Results: Following pneumoperitoneum rise in systolic blood pressure (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and heart rate (HR) was higher in P group in comparison to M group which was statistically significant.
Conclusion: Significant rise in HR, SBP, DBP, and mean BP was noted in the P group in comparison to moxonidine group. Moxonidine provided better preoperative hemodynamic stability in patients undergoing laparoscopic surgeries.
Keywords: Laparoscopic surgery, moxonidine, pneumoperitoneum, hemodynamic changes.
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