Title: Ratio of Atherogenic and Antiatherogenic Lipoproteins in RVO
Authors: Dr Samreen Rafique Shaikh, Dr Pooja Nitin Joshi, Dr Arif Ansar Shaikh
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.94
Abstract
Retinal vein occlusion is the most common retinal vascular disease after diabetic retinopathy. Due to its multifactorial nature, diagnosis and management remains a challenge. Hyperlipidemia is one of the risk factors. So a case control study was undertaken to determine levels of serum lipids and ratios of atherogenic to antiatherogenic lipoproteins. Total 60 patients of the study were divided into group A (30 patients of fundoscopically diagnosed RVO) and Group B (30 age and sex matched controls). The levels of Total Cholesterol, Triglyceride, Low Density Lipoprotein, Very Low Density Lipoprotein, High Density Lipoprotein and ratios of atherogenic (TG,LDL) to antiatherogenic (HDL) lipoproteins were measured. The results obtained in these patients were compared to those of controls. Data analysis was performed using Graph Pad Instat software, Version 3.05. A highly significant increase in serum levels of TG, VLDL-C (p<0.001), and a significant increase in the serum levels TC and LDL-C (p<0.05) was found in group A as compared to that of group B. However no significant decrease was found in the serum levels of HDL-C (p>0.05) in group A as compared to that of group B. There was highly significant increase in TG/HDL ratio (p<0.001) and significant increase in LDL/HDL ratio (p<0.05). The study concluded that elevated ratios of TG/HDL and LDL/HDL may contribute to the pathogenesis and progression of RVO and lowering the levels of these parameters may prevent the further complications of RVO.
Keywords: RVO, atherosclerosis, Triglycerides, Low density lipoprotein, High density lipoprotein, small density lipoproteins.
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