Title: Clinical Profile and Complications in Sickle Cell Disease and Its Variants in Central India
Authors: Ashwin D K, T N Dubey, R S Saxena, Harsha H B, Gopal Krishna
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.89
Abstract
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Objective: Sickle cell anemia is a hereditary anemia, with nearly 50% of the world population affected by sickle cell disease reside in India. Complications of sickle cell disease increases morbidity. This study was designed to asess the clinical profile and complications of sickle cell anemia and its variants. Method: Hospital based cross-sectional observational study was undertaken among adolescent and adult patients conducted at Hamidia Hospital Bhopal. A total of 50 patients were studied and analysed. Clinical features and complications were noted and compared with previous studies. Results: Males are found to be predominantly affected by sickle cell disease with male to female ratio of nearly 3:2.Most common symptoms of presentation are Bone pain and Abdominal pain. Most common signs are Pallor, Fever and Splenomegaly. Splenomegaly was found more common in the adolescent age group. Vaso-occlusive crisis is the most common crisis of presentation. |
References
1. Weatherall DJ, Clegg JB(2001).”inherited haemoglobin disorders:an increasing global health problem”. Bull. World Health Organ.79(8):704 12.PMC2566499. PMID11545326.//www.ncbi.nlm.nih.gov/pmc/articles/.PMC2566499.
2. Meshikhes AW,al-Faraj AA.Sickle cell disease and the general surgeon.J R Coll Surg Edinb 1998;43(2):73-79.
3. DeBaun MR, Jones MF, Vichinsky E.Sickle Cell Disease in Nelson text book of Pediatrics 19th edition. Behrman RE, Kleigman RM, Jenson HB, Saunders Phildelphia,2011;456:1663-1670
4. Kamble M, Chatruvedi P. Epidemiology of sickle cell disease in a rural hospital of central India. Ind Pediatr 2000; 37: 391-396.
5. Dangi C, Sajid M, Sawke G K, Ambhore J. Sickle cell hemoglobinopathies in district Bhopal. Indian J Hum Genet 2010;16:100-2.
6. Kar BC, Satyabhama Devi : Clinical profile of Sickle Cell disease in Orissa.
7. Indian J Pediatrics 1997;64:73-77
8. Kar BC; Sickle cell disease in India, JAPI 1991; Volume 39 (12) ;954-960
9. Vasundhara M, Ramdas R,Bhagya Lakshmi A, Satish Kumar S, Subash R.Study of sickle cell anemia with clinical and hematological correlation. Int J Res Med Sci2016;4:246-51.
K Swarnkar, A Kale, B Lakhkar. A Clinico-Epidemiological and Hematolo-gical Profile of Sickle cell Anemia with special reference to Pencillin prophy-laxis in a rural Hospital of central India. Internet Journal of Epidemiology.2010 Volume 9 Number 2.