Title: Correlation of Serum T3, T4, TSH with Chronic Kidney Disease
Authors: Dr Nirali Salgiya, Dr Nilesh Kumar Patira, Dr Deepak Agrawal
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.71
Abstract
Aims and Objectives: Correlation of serum T3, T4, TSH with Chronic kidney disease patients.
Material and Methods: The present study was undertaken at Maharana Bhupal Govt. Hospital, attached to R.N.T. Medical College Udaipur (Raj.).
· Patients admitted with sign and symptoms due to deranged renal functions were stratified into stages of CKD according to guidelines of the National Kidney Foundation [Kidney Dialysis Outcomes Quality Initiative (KDOQI)]
· Methods of measurement of GFR: Cockroft-Gault formula was used.
· Clinical history was recorded including age, sex, weight, height, primary renal diagnosis, and Blood pressure, history of diabetes and smoking.
· Blood samples were collected in the non-fasting state.
· Descriptive statistical analysis was carried out in this study.
Observation and Conclusion: In this study population, 100 patients of various stages of CKD (II to V) were included. They were non-diabetic, and were not on dialysis.
Serum T3 differed between chronic kidney disease stages, being more commonly decreased in more advanced chronic kidney disease. Serum T4 differed between chronic kidney disease stages, being more commonly decreased in more advanced chronic kidney disease. Serum TSH differed between chronic kidney disease stages, being more commonly increased in more advanced chronic kidney disease. Prevalence of hypothyroidism with chronic kidney disease was 31% .31 out of 100 patients had hypothyroidism. Out of which 29 had subclinical hypothyroidism (0% in stage II, 16% in stage III, 40% in stage IV, and 60% in stage V) and 2 had overt hypothyroidism (8% in stage V).
According to this study all CKD patients should undergo for thyroid function evaluation as these patients are definitely associated with development of hypothyroidism.
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