Title: Use of Myo-inositol for Ovulation Induction in Patients with Polycystic Ovary Syndrome
Authors: Dr Tabassum Ahmed, Dr Renu Rohtagi, Dr Punit Hans
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.66
Abstract
Objectives: Administration of isoform of inositol (myo-inositol) belonging to Vitamin B complex would improve insulin receptor activity, in restoring normal ovulatory function.
Method:25 PCOS patients of child bearing age were enrolled in the study. Only ovulatory disorders due to PCOS were included in the study. All other factors of infertility were excluded.
Myo-inositol combined with folic acid 2 gram twice daily was administered continuously for a period of six months Ovulation was assessed by ultrasound scan and hormonal profile and number of spontaneous menstrual cycle eventual pregnancies were assessed
Result: 20 out of 25 (80%) patients restored at least one spontaneous menstrual cycle. During treatment of whom 16 (64%)had normal ovulatory activity during follow up period.A total of 12 singleton pregnancy (48%) occurred. 2 pregnancies terminated in spontaneous abortion.
Conclusion: Myo-inositolis a simple and safe treatment for ovulation induction and subsequent pregnancy. The therapy did not cause multiple pregnancy.
Keywords: PCOS, Ovulation induction, Myo-inositol
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