Title: Study of Patients with Non Alcoholic Fatty Liver Disease and its Association with Metabolic Syndrome in tertiary centre
Authors: Dr P.Asati, Dr P.Kukrele, Dr Sarita Jalodiya
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.16
Abstract
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NAFLD Nonalcoholic fatty liver disease (NAFLD) is emerging as an important cause of liver disease in India. NAFLD includes patient with simple steatosis, as also those with non alcoholic steatoheaptitis (NASH). NASH is more advanced stage of NAFLD and has a higher risk of progressing to liver cirrhosis or hepato cellular carcinoma[1].NAFLD frequently associated with metabolic syndrome, obesity, Type-2 diabetes mellitus and hyper lipidaemia are co-existing conditions frequently associated with NAFLD. Because of the strong association with various metabolic abnormalitites, NAFLD is now considered as a part of spectrum of metabolic syndrome. the present study is aimed to evaluate the clinical, biochemical profile in patients of NAFLD with varying degree of severity as diagnosed by ultrasonography and evaluate the association between the non-alcoholic fatty liver disease and the metabolic syndrome and its individual components as defined by the NCEP ATP III criteria. |
Results:51% of patients with NAFLD had metabolic syndrome and statistically significance was found in AST, waist circumference, lipid profile total cholesterol was significantly higher in grade III NAFLD which was significantly higher. AST ALT values were significantly higher among grade III NAFLD Cases (p value <0.001,<0.001 respectively.
References
1. Bedogni G. MiglioliL.,Masutti F, Trilibeli C, Merchesini G, Bellentani S, prevalence and risk factor for non alcoholic fatty liver disease : the Dionysis nutrition and liver study. Hepatology . 2005july;42(1):44-52
2. Angulo P. Non alcoholic fatty liver disease NEngl J Med.2002apr18; 346(16):1221-31
3. Adams LA,lymp JF . St Sauver Jet al the natural history of nonalcoholic fatty liver disease: a population based cohort study. Gastroenterology 2005(Jul);129(1):113-121
4. Marchesini G, Brizi M, Bianchi G et al. non alcoholic fatty liver disease a feature of the metabolic syndrome. diabetes 2001Aug ; 50 (8): 1844-1850.
5. Third report of the National Cholesterol Education Programme (NCEP) Expert panel on Detection Evaluation and Treat-ment of High Blood Cholesterol in Adults (Adults Treatment panel III) final report circulation.2002 Dec17 106(25):3143-421.
6. Grundy SM ,cleeman JI , Danids SR , et al. Diagnosis and management of the metabolic syndrome : An American Heart association / National Heart , Lung and blood institute scientific statement , circulation 2005oct 25 : 112(17) : 2735-52
7. SanyalAJ . AGA Technical review on non alcoholic fatty liver disease Gastroenteroloy 2002 ; 123 : 1705-25.
8. Roti Agrawal ,sunita Mishra , VK Dixit & Sweta Rai. Association ofnon alcoholic fatty liver disorder with obesity . Indian J PrevSoc med. 2008 ; 39 : 13-16.
9. Duseja Ajay, Das Ashim , Das Reena, Dhiman RK, Chawla Y, BhansaliA,Kalra Naveen. The clinicopathological profile of indian patients with non alcoholic fatty liver disease(NAFLD) is different from that in the west.Dig dis Sci 2007 Sep;52(9):2368-2374.
10. Uchida Deepa,Pipalia D, Chawla M, Patel R, Maniarsonali, Narayani Juneja Archana. Non-Alcoholic fatty liver disease (NAFLD)- The Hepatic component of Metabolic syndrome.Jassoc Physicians india 2009;57:201-204.
11. Nomora H, KashiwagiS,Hayashi ,et al. Prevalence of fatty liver in the general population of Okinawa, Japan. Japanese Journal of Medicine 1998; 27: 142-149.
12. Singh SP, Nayak S , Swarn M ,et al. Prevalence of NAFLD in eastern coastal India-A Preliminary USG study. Tropical Gastroenterology 2004; 2: 76 – 79.