Title: Evaluation of Effect of Infusion of Dexmedetomidine on Attenuation of Hemodynamic Response During Laparoscopic Surgeries
Authors: Dr S.D.Yennawar, Dr Nazima Y Memon, Dr N.K Nandanwankar
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.08
Abstract
Background: Laparoscopic Surgeries have recently gained much popularity because of its minimal invasiveness and fast recovery. These surgeries require creation of Pneumoperitoneum with carbon dioxide which results in undesirable hemodynamic effects. To overcome these effects various drugs have been tried. Recently dexmedetomidine, a selective α-2 agonist, is used for same purpose. Various studies have found that use of dexmedetomidine is associated with blunting of haemodynamic instability associated with creation of Pneumoperitoneum for the purpose of laparoscopic surgeries.
Aims and Objectives: The purpose of the study was (1) To study the effect of dexmedetomidine on attenuation of hemodynamic responses associated with Pneumoperitoneum during laparoscopic surgeries (2) To study the incidence of adverse effects like bradycardia, hypotension, and Postoperative nausea and vomiting (3) To study the effect on postoperative pain relief.
Material and Methods: The study included 60 patients of ASA grade I/II divided into two groups, Group A (n=30) Patients received Dexmedetomidine infusion 1mcg/kg/min over 10 minutes prior to induction followed by dexmedetomidine infusion at 0.3 mcg/kg/min till end of surgery. Group B (n=30) received normal saline infusion at same rate.
Conclusion: Patients receiving dexmedetomidine infusion had better hemodynamic profile without any significant side effects than patient receiving saline infusion. Also the requirement of analgesic in postoperative period was reduced significantly in dexmedetomidine group. Moreover incidence of adverse effects like bradycardia, hypotension and Postoperative vomiting was considerably less in patients who received dexmedetomidine.
Keywords: Laparoscopic surgery, Pneumoperitoneum, Dexmedetomidine, hemodynamic response.
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