Title: Carcinoma Breast- A Single Center Study
Authors: Amit Mittal, CSBR Prasad, Sreeramulu P.N, Srinivasan D, Naveed Ahmed Khan, Ruta Ujjval Joshi
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.03
Abstract
Objective: The role of hormone receptors as a prognostic and therapeutic tool in breast cancer is widely accepted. The aim of this study was to analyse the receptor status in breast cancer with histopathological characteristics of the tumor.
Methods: In the present study, immunohistochemical assay of 62 tumor block of patients of breast carcinoma was performed to know the hormone receptor status as well as histological examination.
Results: 62 samples were taken to study hormonal status and their relation with histo-pathological factors. Out of 62 breast cancer specimen available for immunohistochemical testing for ER/PR. The result of the study showed 45.16% cases were ER+/PR+, 4.84% cases ER+/PR-, 6.45% ER-/PR+ and 43.55% cases were ER-/PR-.A significant association was seen between histologic grade and hormone receptor status
Conclusion: The Estrogen receptor and Progestron Receptor negative cases were found to be high grade disease on histological evaluation. The ER/PR status of all breast tumour should be evaluated for IHC. ER/PR positive breast tumour has better prognosis and respond better to treatment.
Keywords: Breast carcinoma, Estrogen, Progesterone,Histopathology.
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