Introduction: The diabetes mellitus is a metabolic disorder and forthcoming epidemic all over the globe that is caused due to insulin resistance. In this background the adipokine-leptin could be potential and beneficial alternative treatment modality. Leptin promotes weight loss, regulation of appetite & can reverse diabetes by improving glucose tolerance by its action on hypothalamus.

Objectives: Present study will be conducted to evaluate the role of leptin in obesity associated maturity onset diabetes. Other biochemical markers such as TRIGLYCERIDES, Total CHOLESTEROL, HDL, LDL, Adiponectin, tumor necrosis factor and insulin would also be studied as they are associated with obesity of patient and insulin resistance. This study has been approved by ethical committee of the institution.

Methods: Study was performed as a randomized controlled trial and with parallel design. Physical examination and preliminary lab investigations patients of obesity induced DM will be selected. Serum glucose, cholesterol, triglycerides, HDL, LDL and HbA1c will be performed on semi auto analyzer according to the methodology & instructions given on literature accompanying commercially available kits of ERBA^TM.

Results: Study was done on 200 patients with type 2 diabetic patients to analyze the role of Leptin hormone in obesity induced type 2 DM. In the present study type-II diabetes patients were had significantly higher fasting blood glucose (P<0.001), glycosylated hemoglobin [HbA1c] (P <0.001), cholesterol (P=0.015) and high-density lipoprotein (P = 0.009), Low-density lipoprotein (<0.001) and non-significantly triglycerides (0.066) were observed. Further type-II diabetes patients were had significantly higher insulin (P<0.001), TNF- α (P <0.001), Leptin (P<0.001) and high adiponectin (P=0.001) were observed.

Conclusion: Although Type 2 diabetes can be treated with oral hypoglycemic drugs for long time but ultimately they require insulin to control their diabetes which has its side effects & available in injectable form only which is very cumbersome for the patient. Therefore it is necessary to look for other alternative therapy which has lesser side effects. Leptin together with other molecules that are secreted from adipose tissue does affect the insulin sensitivity & is accepted to play a major role in pathogenesis of obesity related diabetes.

Keywords: Diabetes, Obesity, Glucose, Leptin.

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Jaipal Singh

Department of Medical Biochemistry, Faculty of Medical Sciences,

Geetanjali Medical College, Geetanjali University, Udaipur [Rajasthan], India

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