Title: Hydroxyzine induced Paroxysmal Supraventricular Tachycardia in a Neonate- an Extremely Rare Case
Authors: Dr Sandhya Chauhan, Dr Pancham Kumar, Dr Ashok Garg
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.201
Abstract
A wide range of drugs have been implicated in the development of cardiac arrhythmias. Amongst them are the rarely reported drugs like hydroxyzine and some other antihistamines. Hydroxyzine induced cardiac arrhythmias oftenly occur with drug overdosage in pediatric population. Paroxysmal supraventricular tachycardia (PSVT) is a type of tachyarrhythmia rarely suspected in neonates secondary to hydroxyzine. Here we report twenty seven day old baby with life threatening PSVT secondary to hydroxyzine. It was the development of generalised rash on third day of viral illness which forced the parents to give over the counter (OTC) antiallergic syrup in view of drug reaction. After 3rd dose of this (hydroxyzine), syrup a sick baby was admitted with unstable vitals, compromised cardiopulmonary functions with ECG evidence of PSVT. Baby was managed with adenosine injection and supportive measures. A detailed workup revealed the possibility of hydroxyzine induced PSVT after exclusion of all other causes. Clinician must be aware of drug induced arrhythmias in neonates, because fatalities can be avoided by early treatment along with weaning of culprit drug.
Key Words: PSVT, Hydroxyzine, Pediatric, Cardiac arrhythmia.
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