Title: Platelet-Rich Fibrin: Role in Periodontal and Pulpal Regeneration
Authors: Shahana C Mohamed, Subija K Narayanan Kutty
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.190
Abstract
Platelets are reservoirs of growth factors and cytokines and play a crucial role in wound healing and regeneration of tissues. Literature review suggests an important role of platelet concentrates in periodontal and pulpal regeneration. Platelet-rich fibrin is a second generation platelet concentrate which contains platelets and growth factors in the form of fibrin membranes prepared from the patient’s own blood free of any anticoagulant or other artificial modifiers. This article briefly describes the role of platelet-rich fibrin in periodontal and pulpal regeneration.
Keywords: Platelet-rich fibrin, Platelet concentrates, Regeneration.
References
1. Guo S, DiPietro L. Factors Affecting Wound Healing: J Dent Res. 2010 Mar;89(3):219-29.
2. Greening DW, Sparrow RL, Simpson RJ. Preparation of platelet concentrates. Methods Mol Biol. 2011;728:267-78.
3. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158-67.
4. Dohan Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014;4(1):3-9.
5. Peck M, Hiss D, Stephen L, Satti A, Majeed A. Platelet- Rich Fibrin (PRF) - The effect of storage time on platelet concentration. South African Dental Journal. 2015;70:448-51.
6. Choukroun J, Adda F, Schoeffler C, Vervelle A. An opportunity in perio-implantology: The PRF (in French)Implantodontie 2001;42:55-62.
7. Agrawal M, Agrawa V. Platelet Rich Fibrin and its Applications in Dentistry-A Review Article. National Journal of Medical and Dental Research. 2014;2(3):51-8.
8. Preeja C, Arun S. Platelet-rich fibrin: Its role in periodontal regeneration. The Saudi Journal for Dental Research. 2014;5(2):117-22.
9. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):19.
10. Pluemsakunthai W, Kuroda S, Shimokawa H, Kasugai S. A basic analysis of platelet-rich fibrin: distribution and release of platelet-derived growth factor-BB. Inflammation and Regeneration. 2013;33(3):164-72.
11. Ross R, Glomset J, Kariya B, Harker L. A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro: Proc Natl Acad Sci U S A. 1974 Apr;71(4):1207-10.Malathi K, Muthukumaraswamy A, Beri S. The combination therapy using platelet rich fibrin with demineralised bone matrix poses to be a rapid, effective and promising grafting modality for the management of intrabony osseous defects. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2013;4(2):20-6.
12. Chen F, Sheiton R, Jin Y, Chapple I. Localized delivery of growth factors for periodontal tissue regeneration: role, stratergies, and perspectives. Med res Rev. 2009;29:472-513.
13. Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol. 2011;82(10):1396-403.
14. Anilkumar K, Geetha A, Umasudhakar, Ramakrishnan T, Vijayalakshmi R, Pameela E. Platelet-rich-fibrin: A novel root coverage approach: J Indian Soc Periodontol. 2009 Jan-Apr;13(1):50-4.
15. Sharma A, Pradeep AR. Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol. 2011;82(12):1705-12.
16. Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol. 2011;38(10):925-32.
17. Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol. 2009;80(12):2056-64.
18. Gassling V, Douglas T, Warnke PH, Acil Y, Wiltfang J, Becker ST. Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering. Clin Oral Implants Res. 2010;21(5):543-9.
19. Shivashankar VY, Johns DA, S V, Sam G. Combination of platelet rich fibrin, hydroxyapatite and PRF membrane in the management of large inflammatory periapical lesion. Journal of Conservative Dentistry 2013;16(3):261-4.
20. Gassling VL, Acil Y, Springer IN, Hubert N, Wiltfang J. Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(1):48-55.
21. Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: a review of current status and a call for action. J Endod. 2007;33(4):377-90.
22. Hargreaves KM, Geisler T, Henry M, Wang Y. Regeneration potential of the young permanent tooth: what does the future hold? Pediatr Dent. 2008;30(3):253-60.
23. Shivashankar VY, Johns DA, Vidyanath S, Kumar MR. Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex. J Conserv Dent. 2012;15(4):395-8.
24. Khetarpal A, Chaudhry S, Talwar S, Verma M. Endodontic management of open apex using MTA and platelet – rich fibrin membrane barrier: A newer matrix concept: J Clin Exp Dent. 2013 Dec;5(5):e291-4.
25. Rudagi KB, Rudagi B. One-step apexification in immature tooth using grey mineral trioxide aggregate as an apical barrier and autologus platelet rich fibrin membrane as an internal matrix: J Conserv Dent. 2012 Apr-Jun;15(2):196-9.
26. Bains R, Bains VK, Loomba K, Verma K, Nasir A. Management of pulpal floor perforation and grade II Furcation involvement using mineral trioxide aggregate and platelet rich fibrin: A clinical report: Contemp Clin Dent. 2012 Sep;3(Suppl 2):S223-7.
27. Johns DA, Shivashankar VY, Maroli RK, Vidyanath S. Novel management of avulsed tooth by pulpal and periodontal regeneration. J Endod. 2013;39(12):1658-62.