Title: A Rare Case of Solitary Plexiform Neurofibroma of Tongue: A Case Report and Review of Literature
Authors: Dr R. Keerthi, Dr Rudra Paul Nandan
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.167
Abstract
The neurofibroma occurs as an isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF1)3. A case of a sixty year old female with a solitary growth on the dorsum of tongue treated by total excision, diagnosed with plexiform neurofibroma based on immunohistochemistry marker S-100 is presented. She was having no other signs of any such lesions elsewhere in the body. Despite their occurrence in the head and neck region, this is a very rare finding in the oral cavity and one among 4-7 % of patients reported to be affected by neurofibromatosis displaying oral manifestations. Plexiform neurofibroma is said to be indicative of Von Recklinghausen’s disease (VRD) even though it may be the only manifestation of the disease 2. Ideally surgical resection should be the treatment of choice and the diagnosis has to be confirmed by both histological and immunohistochemistry examination with S-100 tumour marker. Affected patients need thorough clinical examination and regular follow up to detect any recurrence, any malignant degeneration, or any manifestations of Von Recklinghausen’s disease.
Key Words: Plexiform Neurofibroma, Von Recklinghausen’s disease, Schwannoma, Neurofibroma.
References
1. Tetsuo S, Takao K, Disuke N, Takahiro K, Norio H, Fumio I,Solitary Neurofibroma of the oral mucosa : A previously undescribed variant of neurofibroma : Journal of oral science: 2002 ;44 ;59-63.
2. Enis A G et al, Plexiform neurofibroma of tongue: a case report of a child ; The Turkish Journal of Pediatrics 2006;48;155-158.
3. Luciana S M, Denise T O , Michele CP, Cleverson TS, Raul NF, Sporadic and multiple neurofibromas in the head and neck region : a retrospective study of 33 years, Clin. Oral Invest;2007;11: 165-169.
4. Aline CBRJ etal, Extraosseous solitary hard palate neurofibroma, Rev Bras Otorrinolaringol, 2008;74 (2);317.
5. Lahoz Zamarro MT, Galve Royo A. Neurofibroma of the tongue. An Otorrinolaringol Ibero Am 1990;17: 287-295.
6. Crozier WC. Upper airway obstruction in neurofibromatosis. Anaesthesia 1987;42: 1209-1211
7. Pardos MD, Neoplasms of the nervous System In: Holland JF, Frei M (eds). Cancer Medicine (5th Edition).London: B.C.Decker Inc;2000: 1055-1082.
8. Gallesio C, Berrone S. Schwannoma located in the tongue. A clinical case report.Minerva Stomatol 1992;41:583-590.
9. Benign tumors of peripheral nerves. In: Weiss SW, Goldblum JR (eds).Enzinger and Weiss’s Soft Tissue Tumors (4th ed.).St Louis: Mosby Inc;2001:1111-1207.
10. Johnson MD, Glick AD, Davis BW. Immunohistochemical evaluation of Leu-7,myelin basic-protein,S100-protein,glial-fibrillary acidic protein, and LN3 immunoreactivity in nerve sheath tumors and sarcomas. Arch Pathol Lab Med 1988:112(2):155-160.