Title: Raised serum IL 6 and CRP in Radiographic Knee Osteoarthritis in Eastern India
Authors: Ravela Malathi, Sanjay Kothari, Abhishek Chattopadhyay, Pradip Kumar Agrawal, Upal Banerjee, Ramesh Kumar Sahu
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.73
Abstract
Background: Osteoarthritis (OA) is the most common age-related joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis.
Aims & Objectives: Therefore, the objective of this study was to investigate the concentration of pro-inflammatory cytokines (IL-6) and CRP in patients with painful knee osteoarthritis CRP in radiographic knee osteoarthritis in eastern India.
Results: ESR and hs-CRP were elevated in RKOA cases as compared to controls which were found statistically significant. Serum IL 6 levels were also increased in RKOA cases as compared to controls and were statistically significant (16.88 ± 7.20 versus 6.68 ± 2.89 pg/ml; P < 0.0001). However, a high positive correlation was observed between ESR with serum IL 6 level (r = 0.917; P =<0.001) among RKOA subjects while no correlation was seen in controls (r = -0.019; P = 0.251).
Conclusion: This study showed that serum levels of IL-6 and CRP were higher in knee OA than in healthy controls. These findings align with a physio-pathological understanding of pain and functionality that surpasses the one which currently provides basis for therapeutics in OA.
Keywords: Osteoarthritis, IL 6, CRP, Radiography, Knee joint, Radiological knee osteoarthritis (RKOA).
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