Title: Preeclampsia Risk and AGT M235T Gene in North India
Authors: Dr Rakesh Kumar Shukla, Dr R.K Srivastava, Dr Anil Kumar, Dr Archana Mishra
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.62
Abstract
Background: Pregnancy induced hypertension is considered to be a multifactorial and multisystemic disorder with a genetic predisposition.
Aim: The aim of this original research article is to investigate the frequency of Angiotensiongen gene (AGT) Polymorphism in hypertension associated pregnancies as preeclampsia & eclampsia with normotensive uncomplicated pregnancies.
Method: This study was done in Rama Medical College & Hospital Kanpur. Blood sample from 102 cases of PIH and 100 cases of normotensive pregnant women collected and genomic DNA from each individual was isolated and genotyped for the M235T polymorphism of the angiotensinogen gene (AGT).
Result: Genomic investigation revealed that genotyped for the M235T deletion polymorphism of the angiotensinogen gene (AGT) is present in hypertension associated pregnancies as preeclampsia & eclampsia and absent in normotensive uncomplicated pregnancies.
Conclusion: Hypertension during the pregnancy is associated with M235T polymorphism of the angiotensinogen gene (AGT).
Keywords: PIH, Preeclampsia, Eclampsia, M235T, Angiotensinogen Gene, AGT, Pregnancy, Hypertension.
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