Title: Clinical Profile and Outcome of Preterm with Thrombocytopenia
Authors: Dr Amutha .J, Dr Ramesh S
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.44
Abstract
This study intends to find out thrombocytopenia related clinical profile and outcome in preterm neonates (<37 weeks). In our study 108 preterm neonates admitted in NICU of RMMCH Chidambaram with thrombocyto-penia were studied. The prevalence of thrombocytopenia in preterm in our study is 11.25%. The majority of thrombocytopenia (87.96%) was diagnosed before 72 hrs of age. It was mild 66.67%, moderate 25% and severe 8.33% % of cases.
Keywords: Neonatal thrombocytopenia, Sepsis, Respiratory distress, Congenital malformations, Neonatal intensive care unit, Neurodevelopment.
References
1. Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States National Reference for fetal growth. Obstet Gynecol 1996; 87: 16
2. Castle V, Andrew M, Kelton J, Giron D, Johnston M, Carter C. Frequency and mechanism of neonatal thrombocyto-penia. J Pediatr 1986; 108: 749–7
3. Mehta P, Vasa R, Neumann L, Karpatkin M. Thrombocytopenia in the high risk infant. J Pediatr 1980, 97: 791
4. Murray NA. Evaluation and treatment of thrombocytopenia in the neonatal inten-sive care unit. Acta Paediatr Suppl 2002; 438: 74
5. Lea,Bonifacio, Anna Petrova, Shakunthala Nanjundasamy, Rajeev Metha thrombo-cytopenia related neonatal out comes in preterm. Jpediatrics 2005
6. Beiner ME, Simshen MJ, Sivan E, Chetrit A, Kuint J, Schiff E. Risk factor for neonatal thrombocytopenia in preterm infants. Am J Perinatol 2003; 20: 49–54
7. Hunter Richardson DK, Billett H.H. Inter-NICU variation in rates and management of thrombocytopenia among very low birth-weight infants. J Perinatol 2003; 23: 312–316.
8. Lupton BA, Hill A, Whitfield MF, Carter CJ, Wadsworth LD, Roland EH. Reduced platelet count as a risk factor for intraventricular hemorrhage. Am J Dis Child. 1988;142:1222–1224
9. Guida JD, Kunig AM, Leef KH, McKenzie SE, Paul DA. Platelet count and sepsis in very low birth weight neonates: is there an organism specific response? Pediatrics 2003;111:1411–1415
10. Kling PJ, Hutter JJ. Hematologic abnormalities in severe neonatal necrotizing enterocolitis: 25 years later. J Perinatol 2003; 23: 523–53
11. Maayan-Metzger A, Linder N, Marom D, Vishne T, Ashkenazi S, Sirota L. Clinical and laboratory impact of coagulase-neg-ative staphylococci bacteremia in preterm infants. Acta Paediatr 2000; 89: 690–693.
12. Andrew M, Castle V, Saigal S, Carter C, Kelton J. Clinical impact of neonatal thrombocytopenia. J Pediatr 1987; 110: 457–464
13. Sola MC. Evaluation and treatment of severe and prolonged thrombocytopenia in neonates. Clin Perinatol 2004; 31:
14. Andrew M, Vegh P, Caco C, Kirpalani H, Jefferies A, Ohisson A, Watts J, Saigal S, Milner R, Wang E. A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants. J Pediatr 1993; 123: 285
15. Del Vecchio A, Sola MC, Theriaque DW, Hutson AD, Kao KJ, Wright D, Garcia MG, Pollock BH, Christen RD. Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion 2001; 41: 803–808.
16. Garcia MG, Duenas E, Sola MC, Hutson AD, Theriague D, Christensen RD. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. J Perinatol 2001; 21: 415