Title: Renal Cell Carcinoma- A Morphological Profile
Authors: Dr Ashida M Krishnan, Dr Meera Arun, Dr Sauda V M
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.36
Abstract
Introduction: Renal Cell accounts for nearly 3% of all adult malignancies globally and comprises 80-90% of all malignant renal tumors in adult life. The morphological parameters like the histopathologic variant and its nuclear grade determine the aggressiveness of Renal Cell Carcinoma.
Methods: 49 cases who underwent radical/partial nephrectomy specimens in a tertiary health care centre over a span of 2years were selected. Their gross and microscopic features were studied and results were correlated with the clinical features.
Results: Renal cell carcinoma shows varying morphologic features in gross and histologic appearance. The predominant histologic variant is Clear cell variant and predominant nuclear grade of tumours was grade II. There was no correlation between clinical features and grading. Radiological studies have a high sensitivity in detecting Renal cell carcinoma.
Conclusion: Thorough evaluation of morphological parameters in Renal Cell Carcinoma is very essential for planning therapy and predicting the disease outcome.
Keywords: Kidney, Renal cell carcinoma, Clear cell carcinoma.
References
1. Storkel S, Eble JN, Adlakha K, et al. Classification of renal cell carcinoma: Workgroup No. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Commettee oc Cancer (AJCC). Cancer 1997;80:987-9.
2. Amin MB, Amin MB, Tamboli P,et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms:an experience of 405 cases. Am J Surg Pathol 2002;26:281-91.
3. Crotty TB, Farrow GM, Lieber MM. Chromophobe cell renal carcinoma: clinicopathologic features of 50 cases. J Urol 1995;154:964-7.
4. Chao D, Zisman A, Pantuck AJ,et al. Collecting duct renal cell carcinoma: clinical study of a rare tumor. J Urol 2002;167:71-4.
5. Akthar M, Tulbah A, Kardar AH,et al. Sarcomatoid renal cell carcinoma: the chromophobe connection. Am J Surg Pathol 1997;21:1188-95.
6. Venturina M, Moch H, Amin M. Sarcomatoid differentiation in renal cell carcinoma. Am J Surg Pathol 2001;25:275-84.
7. Volpe A, Jewett MA. The natural history of small renal masses. Nat Clin Pract Urol 2005; 2(8):384-90.
8. AJ Pantuck, A Zisman, As Belldegrun - The Changing Natural History Of Renal Cell Carcinoma The Journal Of Urology, 2001 Elsevier Association, : Review Articles.
9. Riches EW and Thackray AC. Griffiths IH Ronald M. Bukowski, Andrew C. Novick Manifestations of renal cell carcinoma Molecular Biology and Immunology .Urology, 8(1976)201-206.
10. Medeiros LJ, Gelb AB, Weiss LM. ,Schoenberg M, Cairns P, Brooks JD, M, Warter A, Roos M, Bollock C. Renal cell carcinoma: statistical study of survival American Journal of Surgical Pathology. June 1997;21(6):621-630.
11. Bretheau D, Lechevallier E, Fromont M, Sault MC, Rampal M, Coulange C. Prognostic value of nuclear grade of renal cell carcinoma. Cancer 1995; 76: 2449 549.
12. Mancille- Jimenez R, Stanley RJ. management of renal cell carcinoma. A clinical and pathologic study . Eur J Cancer --1980; 16: 833-40.
13. Mostofi FK, Davis CJ, , Sesterhenn IA, : Renal carcinoma: clinicopathological study . J Urogen Path 1991; 1; 41-52.
14. Moch H, Gasser T, Amin MB, Torhorst J, Renal Cancer study report .Cancer 38:2469–2480
15. Motzer RJ,Mazumdar M, Bacik J, et al: Survival and prognostin stratification of 670 patients with advanced renal cell carcinoma. J clin Oncol 1999; 17:2530-2540.