Title: Serum Uric Acid Levels As an Independent Short Term Prognostic Marker in Acute Myocardial Infarction
Authors: Dr Padmakumar Rajasekhara Pillai, Dr Suresh Muthezhathu Kesavadas
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.226
Abstract
Background of study
Studies have shown that elevated serum uric acid level is highly predictive of mortality and morbidity in patients with coronary heart disease. Uric acid is an indicator for increased oxidative stress. Xanthine oxidase, a critical enzyme in degradation of purines to uric acid has shown to be an important source of superoxide free radical. Activity of xanthine oxidase increases during ischemia, clinically hyperuricemia occurs in hypoxic states. The goal of the study was to assess the prognostic value of serum uric acid in the outcome of acute myocardial infarct, both mortality and morbidity. Xanthine oxidase activity and uric acid synthesis are increased in vivo under ischemia and hence elevated uric acid may act as a marker for ischemia.
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