Title: Association between Serum Malondialdehyde and Insulin in Type 2 Diabetes Mellitus in Eastern India
Authors: Vineet Kumar Khemka, Ravela Malathi, Anindita Banerjee, Pradip Kumar Agrawal, Chandra Narayan Gupta, Vijay Raghavan
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.221
Abstract
Objectives: Oxidative stress and insulin plays a pivotal role in the pathogenesis of type 2 diabetes mellitus (T2DM). The aim of our study was to study the altered levels of serum insulin and malondialdehyde and putatively establish their association in T2DM individuals.
Methods: The preliminary case-control study included age, sex and body mass index (BMI) matched 56 T2DM cases and 42 healthy control subjects. Serum MDA was measured using a spectrophotometer while fasting serum levels of insulin was measured by commercially available immunoassay kits as well as routine biochemical parameters were analyzed in all study and control subjects.
Results: Serum MDA level was observed significantly higher among T2DM subjects with respect to controls (p < 0.0001). An increase in serum insulin levels were also found in T2DM cases as compared to controls and were statistically significant (p < 0.0001). Further, serum MDA level showed a significant weak positive correlation with fasting plasma insulin (r = 0.265; P = 0.047) level among T2DM subjects, but no significant correlation was observed in controls (r = 0.114; P = 0.471).
Conclusion: The association between serum MDA and insulin suggests that it may be used as a prognostic marker for the pathogenesis of T2DM.
Keywords: Diabetes Mellitus, Oxidative stress, Malondialdehyde, Insulin, Insulin resistance.
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